PMID- 17684290
OWN - NLM
STAT- MEDLINE
DCOM- 20071018
LR  - 20210102
IS  - 1546-3222 (Print)
IS  - 1546-3222 (Linking)
VI  - 4
IP  - 5
DP  - 2007 Aug 15
TI  - Role of CD4+ T cells in sarcoidosis.
PG  - 461-4
AB  - Activated pulmonary CD4(+) T lymphocytes of the Th-1 type are essential for the 
      inflammatory process in sarcoidosis, and IFN-gamma production is crucial for the 
      characteristic granuloma formation. Both the T cells and their inflammatory 
      mediators may constitute possible targets for immunotherapy. A particular T-cell 
      subset, the T-cell receptor (TCR) AV2S3(+) bronchoalveolar lavage (BAL) CD4(+) T 
      cells, is found at dramatically increased levels in the BAL fluid of human 
      leukocyte antigen (HLA)-DRB1*0301-positive and/or HLA-DRB3*0101-positive patients 
      with sarcoidosis. The AV2S3(+) BAL CD4(+) T cells strongly associate with the 
      sarcoid inflammation, and future studies on this particular T-cell subset to 
      reveal their specificity may lead to the identification of sarcoidosis-specific 
      antigen(s). T-cell subpopulations with regulatory functions (i.e., natural killer 
      T cells and T regulatory cells) have recently been described as abnormal in 
      sarcoidosis. Dysfunctional regulatory T cells may allow T effector cells to 
      contribute to the formation of granulomas, and they may thus be relevant for the 
      inflammatory process in this disease. These findings are exciting news and will 
      be of help in designing new treatment strategies.
FAU - Grunewald, Johan
AU  - Grunewald J
AD  - Department of Medicine, Division of Respiratory Medicine, Lung Research 
      Laboratory L4:01, Karolinska University Hospital Solna, S-171 76 Stockholm, 
      Sweden. johan.grunewald@ki.se
FAU - Eklund, Anders
AU  - Eklund A
LA  - eng
GR  - HL04-009/HL/NHLBI NIH HHS/United States
GR  - R21HL077579-02/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Proc Am Thorac Soc
JT  - Proceedings of the American Thoracic Society
JID - 101203596
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Sarcoidosis, Pulmonary/*immunology
MH  - T-Lymphocytes, Regulatory/immunology
PMC - PMC2647597
EDAT- 2007/08/09 09:00
MHDA- 2007/10/19 09:00
PMCR- 2008/08/15
CRDT- 2007/08/09 09:00
PHST- 2007/08/09 09:00 [pubmed]
PHST- 2007/10/19 09:00 [medline]
PHST- 2007/08/09 09:00 [entrez]
PHST- 2008/08/15 00:00 [pmc-release]
AID - 4/5/461 [pii]
AID - procats45461 [pii]
AID - 10.1513/pats.200606-130MS [doi]
PST - ppublish
SO  - Proc Am Thorac Soc. 2007 Aug 15;4(5):461-4. doi: 10.1513/pats.200606-130MS.