PMID- 17684493
OWN - NLM
STAT- MEDLINE
DCOM- 20080305
LR  - 20071128
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 12
IP  - 12
DP  - 2007 Dec
TI  - EAAT2 regulation and splicing: relevance to psychiatric and neurological 
      disorders.
PG  - 1065-78
AB  - The excitatory amino acid transporter 2 (EAAT2) is responsible for the majority 
      of glutamate uptake in the brain and its dysregulation has been associated with 
      multiple psychiatric and neurological disorders. However, investigation of this 
      molecule has been complicated by its complex pattern of alternative splicing, 
      including three coding isoforms and multiple 5'- and 3'-UTRs that may have a 
      regulatory function. It is likely that these sequences permit modulation of EAAT2 
      expression with spatial, temporal and or activity-dependent specificity; however, 
      few studies have attempted to delineate the function of these sequences. 
      Additionally, there are problems with the use of antibodies to study protein 
      localization, possibly due to posttranslational modification of critical amino 
      acid residues. This review describes what is currently known about the regulation 
      of EAAT2 mRNA and protein isoforms and concludes with a summary of studies 
      showing dysregulation of EAAT2 in psychiatric and neurological disorders. EAAT2 
      has been either primarily or secondarily implicated in a multitude of 
      neuropsychiatric diseases in addition to the normal physiology of learning and 
      memory. Thus, this molecule represents an intriguing therapeutic target once we 
      improve our understanding of how it is regulated under normal conditions.
FAU - Lauriat, T L
AU  - Lauriat TL
AD  - Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, 
      USA.
FAU - McInnes, L A
AU  - McInnes LA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070807
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Excitatory Amino Acid Transporter 2)
SB  - IM
MH  - Excitatory Amino Acid Transporter 2/*genetics
MH  - Humans
MH  - Mental Disorders/*genetics
MH  - Nervous System Diseases/*genetics
MH  - RNA Splicing/*genetics
RF  - 134
EDAT- 2007/08/09 09:00
MHDA- 2008/03/06 09:00
CRDT- 2007/08/09 09:00
PHST- 2007/08/09 09:00 [pubmed]
PHST- 2008/03/06 09:00 [medline]
PHST- 2007/08/09 09:00 [entrez]
AID - 4002065 [pii]
AID - 10.1038/sj.mp.4002065 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2007 Dec;12(12):1065-78. doi: 10.1038/sj.mp.4002065. Epub 2007 
      Aug 7.