PMID- 17684733
OWN - NLM
STAT- MEDLINE
DCOM- 20080225
LR  - 20191210
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 195
IP  - 2
DP  - 2007 Dec
TI  - Behavioural and neurochemical effects of combined MDMA and THC administration in 
      mice.
PG  - 255-64
AB  - RATIONALE: Cannabis is the most widely consumed drug associated with 
      3,4-methylenedioxymethamphetamine (MDMA) use. OBJECTIVES: This study examines 
      whether low doses of MDMA and delta-9-tetrahydrocannabinol (THC) produce 
      synergistic rewarding/reinforcing effects in mice using the conditioned place 
      preference (CPP) and operant self-administration paradigms. Changes in dopamine 
      (DA) outflow were monitored in the nucleus accumbens (NAC) after single or 
      combined administration of these compounds. RESULTS: MDMA induced a significant 
      CPP at the dose of 10 mg/kg but not at the dose of 3 mg/kg. THC (0.3 mg/kg) by 
      itself was also ineffective in this paradigm. The combined administration of the 
      low dose of MDMA (3 mg/kg) and THC (0.3 mg/kg) produced CPP, whereas the 
      combination of MDMA (10 mg/kg) and THC (0.3 mg/kg) significantly decreased CPP. 
      Animals treated with THC self-administered a sub-threshold dose of MDMA (0.06 
      mg/kg per infusion), while animals receiving vehicle did not. However, THC did 
      not modify the self-administration of an effective dose of MDMA (0.125 mg/kg per 
      infusion). In microdialysis studies, a low dose of THC significantly increased DA 
      outflow in the NAC, while a low dose of MDMA did not. When MDMA was administered 
      before THC, DA levels decreased with respect to THC. However, when THC was 
      administered before MDMA, DA levels were not significantly modified with respect 
      to THC. CONCLUSIONS: These results demonstrate that a low dose of THC modifies in 
      different ways (increases and decreases) the sensitivity of animals to the 
      behavioural effects of MDMA and that THC and MDMA converge at a common mechanism 
      modulating DA outflow in the NAC of mice.
FAU - Robledo, Patricia
AU  - Robledo P
AD  - Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la 
      Salut, Universitat Pompeu Fabra, Barcelona, Spain. patricia.robledo@upf.edu
FAU - Trigo, Jose M
AU  - Trigo JM
FAU - Panayi, Fany
AU  - Panayi F
FAU - de la Torre, Rafael
AU  - de la Torre R
FAU - Maldonado, Rafael
AU  - Maldonado R
LA  - eng
GR  - R01 DA016768/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070808
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - 7J8897W37S (Dronabinol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Conditioning, Operant/drug effects
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Dronabinol/administration & dosage/*pharmacology
MH  - Drug Synergism
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Male
MH  - Mice
MH  - Microdialysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Nucleus Accumbens/metabolism
MH  - Reinforcement, Psychology
MH  - Reward
MH  - Self Administration
EDAT- 2007/08/09 09:00
MHDA- 2008/02/26 09:00
CRDT- 2007/08/09 09:00
PHST- 2006/10/26 00:00 [received]
PHST- 2007/06/24 00:00 [accepted]
PHST- 2007/08/09 09:00 [pubmed]
PHST- 2008/02/26 09:00 [medline]
PHST- 2007/08/09 09:00 [entrez]
AID - 10.1007/s00213-007-0879-8 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2007 Dec;195(2):255-64. doi: 
      10.1007/s00213-007-0879-8. Epub 2007 Aug 8.