PMID- 17684970
OWN - NLM
STAT- MEDLINE
DCOM- 20070913
LR  - 20221207
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 79
IP  - 6
DP  - 2007
TI  - [The role of inflammation factors in development of acute coronary syndrome in 
      patients with type 2 diabetes mellitus and impaired glucose tolerance].
PG  - 60-4
AB  - AIM: To study the levels of inflammatory markers in acute coronary syndrome (ACS) 
      and 6 months after its regression in patients with diabetes mellitus (DM) type 2; 
      to evaluate effects of anxiodepressive disorders on inflammatory markers. 
      MATERIAL AND METHODS: The levels of high-sensitive C-reactive protein (hsCRP), 
      interleukin-6 (IL-6), interleukin-18 (IL-18), monocyte-chemmoattractant-protein-1 
      (MCP-1) and soluble vascular cell adhesion molecules (sVCAM) were measured in 
      blood samples, severity of depressive symptoms and the level of glycated 
      haemoglobin (HbA1c) were assessed in 58 patients with type 2 DM during ACS and in 
      54 patients 6 months after ACS regression. RESULTS: The levels of hsCRP and IL-18 
      correlate significantly with severity of myocardial lesion in ACS (p < 0.002; p < 
      0.009). Measurement of inflammatory markers 6 months after the discharge from 
      hospital shows significant correlation between hsCRP, IL-18 and IL-6 levels; 
      these levels were significantly lower in patients with HbA1c < 6.5% (tight 
      glycemic control); there were associations between severity of depressive 
      disorders and markers of inflammation (hsCRP, IL-18); analysis of MCP-1 and sVCAM 
      levels 6 months after ACS regression shows a decrease of markers in 32-36% cases 
      and an increase of markers in 64-67% cases. CONCLUSION: Complex immunological 
      reactions, chronic hyperglycemia and depresssive disorders play an important role 
      in development of latent inflammation of the vascular wall in patients with type 
      2 diabetes mellitus and ACS.
FAU - Chazova, T E
AU  - Chazova TE
FAU - Masenko, V P
AU  - Masenko VP
FAU - Zykov, K A
AU  - Zykov KA
FAU - Golitsyna, T Iu
AU  - Golitsyna TIu
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Chemokine CCL2/*blood
MH  - Coronary Disease/blood/*etiology
MH  - Depression/blood/complications
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Inflammation/blood
MH  - Insulin Resistance
MH  - Interleukin-18/*blood
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Vascular Cell Adhesion Molecule-1/*blood
EDAT- 2007/08/10 09:00
MHDA- 2007/09/14 09:00
CRDT- 2007/08/10 09:00
PHST- 2007/08/10 09:00 [pubmed]
PHST- 2007/09/14 09:00 [medline]
PHST- 2007/08/10 09:00 [entrez]
PST - ppublish
SO  - Ter Arkh. 2007;79(6):60-4.