PMID- 17685131
OWN - NLM
STAT- MEDLINE
DCOM- 20070823
LR  - 20131121
IS  - 1028-768X (Print)
IS  - 1028-768X (Linking)
VI  - 16
IP  - 2
DP  - 2007 Jun
TI  - The relation between plasma homocysteine level and cardiovascular risk factors in 
      cerebral ischemia.
PG  - 81-5
AB  - PURPOSE: Hyperhomocysteinemia (HHcy) is associated with a higher risk of cerebral 
      ischemia and other vascular thrombosis. Homocysteine is greatly influenced by a 
      broad spectrum of physiological and pathological conditions but the confounding 
      factor for HHcy is unknown in our population, especially in normocreatininemic 
      individuals. It is our aim in this study to elucidate the relation between 
      homocysteine and cardiovascular risk factors, and also describe the distribution 
      of plasma homocysteine level in cerebral ischemia patients with normal serum 
      creatinine level. METHODS: A retrospective study was conducted to understand the 
      frequency of HHcy in cerebral ischemia patients, and the confounding 
      cardiovascular risk factors in HHcy. Patients were classified into two groups by 
      their plasma homocysteine levels; group I patients were those whose level was > 
      or = 12 microM/L whereas group II < 12 microM/L. RESULTS: A total of 218 patients 
      were enrolled. Their plasma homocysteine level ranged from 3.57 to 46.37 microM/L 
      (mean: 10.01 +/- 5.03 microM/L). Group I included 45 patients whereas group II 
      173 patients. The frequency of hypertension, diabetes mellitus and cardiac 
      disease, as well as age, aminotransferases, total cholesterol, triglyceride, 
      albumin, hematocrit, hemoglobin and leucocyte count did not differ between group 
      I and II patients, except serum creatinine level was higher in group I patients 
      (p < 0.01). Serum creatinine level correlated directly to and was an independent 
      predictor for the plasma homocysteine level. CONCLUSIONS: HHcy is common in our 
      cerebral ischemia patients. Since renal function is a determinant for HHcy even 
      in normocreatininemic patients, as a cardiovascular risk factor which detriments 
      the renal function, it should be regularly monitored as HHcy is amenable for 
      treatment.
FAU - Huang, Chi-Wei
AU  - Huang CW
AD  - Department of Neurology, Chang Gung Memorial Hospital-Koahsiung Medical Center 
      and College of Medicine, Chang Gung University, Kaohsiung, Taiwan.
FAU - Chen, Tsung-Hua
AU  - Chen TH
FAU - Lin, Hung-Sheng
AU  - Lin HS
FAU - Tseng, Yu-Lung
AU  - Tseng YL
FAU - Lai, Shung-Lon
AU  - Lai SL
FAU - Chen, Wei-Hsi
AU  - Chen WH
FAU - Chen, Shun-Sheng
AU  - Chen SS
FAU - Liu, Jia-Shou
AU  - Liu JS
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Acta Neurol Taiwan
JT  - Acta neurologica Taiwanica
JID - 9815355
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Ischemia/*blood
MH  - Cardiovascular Diseases/*etiology
MH  - Creatinine/blood
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2007/08/10 09:00
MHDA- 2007/08/24 09:00
CRDT- 2007/08/10 09:00
PHST- 2007/08/10 09:00 [pubmed]
PHST- 2007/08/24 09:00 [medline]
PHST- 2007/08/10 09:00 [entrez]
PST - ppublish
SO  - Acta Neurol Taiwan. 2007 Jun;16(2):81-5.