PMID- 17686009
OWN - NLM
STAT- MEDLINE
DCOM- 20071203
LR  - 20220321
IS  - 0904-2512 (Print)
IS  - 0904-2512 (Linking)
VI  - 36
IP  - 8
DP  - 2007 Sep
TI  - Stromal myofibroblasts in central giant cell granuloma of the jaws cannot 
      distinguish between non-aggressive and aggressive lesions.
PG  - 495-500
AB  - OBJECTIVE: To investigate correlations between myofibroblast density (MFD) and 
      biological behavior of a large series of non-aggressive and aggressive central 
      giant cell granuloma lesions (CGCGs). METHODS: Twenty-four non-aggressive and 17 
      aggressive lesions were immunohistochemically stained with alpha smooth muscle 
      actin. MFD was assessed using the point counting method in the lesions' core 
      tissue and in control areas that consisted of non-involved, connective tissue 
      surrounding the lesion. RESULTS: All CGCGs contained myofibroblasts among the 
      stromal cells. No significant differences were found in the mean percentage of 
      MFD (%MFD) of non-aggressive (20.8 +/- 15.7%) and aggressive (23.7 +/- 22.9%) 
      lesions (P > 0.05) or in the mean %MFD of the respective control areas (1.4 +/- 
      2.2% and 1.7 +/- 4.1%; P > 0.05). The mean core tissue %MFD of both lesion types 
      was significantly higher than that of the control areas (P < 0.001). CONCLUSION: 
      Myofibroblasts were an integral component of CGCG stromal cells, but their 
      density could not distinguish between non-aggressive and aggressive lesions.
FAU - Vered, Marilena
AU  - Vered M
AD  - Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela 
      Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel. 
      lmy@netvision.net.il
FAU - Nasrallah, Warda
AU  - Nasrallah W
FAU - Buchner, Amos
AU  - Buchner A
FAU - Dayan, Dan
AU  - Dayan D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (Actins)
SB  - IM
MH  - Actins/analysis
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biology
MH  - Cell Count
MH  - Child
MH  - Child, Preschool
MH  - Connective Tissue/pathology
MH  - Female
MH  - Fibroblasts/*pathology
MH  - Granuloma, Giant Cell/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Jaw Diseases/*pathology
MH  - Male
MH  - Mandibular Diseases/pathology
MH  - Maxillary Diseases/pathology
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Stromal Cells/pathology
EDAT- 2007/08/10 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/08/10 09:00
PHST- 2007/08/10 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/08/10 09:00 [entrez]
AID - JOP541 [pii]
AID - 10.1111/j.1600-0714.2007.00541.x [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2007 Sep;36(8):495-500. doi: 10.1111/j.1600-0714.2007.00541.x.