PMID- 17686102
OWN - NLM
STAT- MEDLINE
DCOM- 20071217
LR  - 20111117
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 62
IP  - 9
DP  - 2007 Sep
TI  - HLA Dr-Dq haplotypes and the TNFA-308 polymorphism: associations with asthma and 
      allergy.
PG  - 991-8
AB  - BACKGROUND: The HLA (human leukocyte antigen) class II genes DQB1 and DRB1 and 
      the Tumor Necrosis Factor alpha gene (TNFA) within the HLA complex (chromosome 
      6p21) have been associated with asthma and allergy. Due to the strong linkage 
      disequilibrium characterizing this complex and the multiple asthma/allergy 
      expressions, we aimed to determine which of these genes were primarily involved 
      in specific asthma/allergy traits. METHODS: The DRB1-DQB1 alleles and TNFA-308 
      polymorphism were genotyped in 959 children from the Environment and Childhood 
      Asthma study and analyzed for possible associations with allergic and 
      non-allergic asthma (with/without at least one positive skin prick test for 
      allergens) and specific allergic sensitization, as well as bronchial 
      hyperresponsiveness and total IgE, using both allele and extended haplotype 
      analyses. RESULTS: Different genes within the HLA complex were associated with 
      separate asthma and allergy traits. Nonallergic asthma was associated with both 
      the TNFA-308A allele [Odds ratio (OR) 1.7 (1.3-2.3)] and DRB1 03 allele [OR 
      1.6(1-2.6)], but extended DRB1 03-TNFA-308 haplotype analysis suggested that the 
      DRB1-DQB1 association was secondary to linkage disequilibrium with the TNFA-308 
      polymorphism. Allergies were associated with HLA class II alleles only; birch 
      sensitization with DQB1 0603-DRB1 13 [OR 2.3 (1.4-4.0)] and mugwort sensitization 
      with DQB1 0609-DRB1 13 [OR 7.1 (1.9-27.0)] and DQB1 0501-DRB1 01 [OR 2.0 
      (1.0-4.0)]. CONCLUSIONS: Our data suggests that asthma is not associated with 
      DRB1 or DQB1 but rather TNFA or a gene(s) in linkage disequilibrium, while 
      sensitization to specific allergens is associated with particular alleles at the 
      DQ and/or DR loci. A novel association between DQB1 0603-DRB1 13 and birch 
      allergy is identified.
FAU - Munthe-Kaas, M C
AU  - Munthe-Kaas MC
AD  - Department of Pediatrics, Ulleval University Hospital, Oslo, Norway.
FAU - Carlsen, K L
AU  - Carlsen KL
FAU - Carlsen, K H
AU  - Carlsen KH
FAU - Egeland, T
AU  - Egeland T
FAU - Haland, G
AU  - Haland G
FAU - Devulapalli, C S
AU  - Devulapalli CS
FAU - Akselsen, H
AU  - Akselsen H
FAU - Undlien, D
AU  - Undlien D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*01 antigen)
RN  - 0 (HLA-DRB1*13 antigen)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Asthma/epidemiology/*genetics
MH  - Child
MH  - Female
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Hypersensitivity/epidemiology/*genetics
MH  - Linkage Disequilibrium
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Norway/epidemiology
MH  - Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2007/08/10 09:00
MHDA- 2007/12/18 09:00
CRDT- 2007/08/10 09:00
PHST- 2007/08/10 09:00 [pubmed]
PHST- 2007/12/18 09:00 [medline]
PHST- 2007/08/10 09:00 [entrez]
AID - ALL1377 [pii]
AID - 10.1111/j.1398-9995.2007.01377.x [doi]
PST - ppublish
SO  - Allergy. 2007 Sep;62(9):991-8. doi: 10.1111/j.1398-9995.2007.01377.x.