PMID- 17686828
OWN - NLM
STAT- MEDLINE
DCOM- 20080102
LR  - 20151119
IS  - 0735-0414 (Print)
IS  - 0735-0414 (Linking)
VI  - 42
IP  - 5
DP  - 2007 Sep-Oct
TI  - Combined effects of systemic alcohol and nicotine on dopamine release in the 
      nucleus accumbens shell.
PG  - 413-6
AB  - AIMS: This study was undertaken to determine whether simultaneous administration 
      of both alcohol and nicotine systemically would result in an additive dopamine 
      release in the nucleus accumbens (NACC). Moreover, to also investigate whether 
      nicotinic receptors may be mediating these effects of alcohol and nicotine, the 
      effects of mecamylamine, a nicotinic receptor antagonist was also evaluated. 
      METHODS: Microdialysis was applied to measure the dopamine overflow in the shell 
      region of NACC. All drugs were administered intraperitoneally. The doses of 
      alcohol ranged from 0.5-2.0 g/kg, and nicotine and mecamylamine 0.25-1.0 mg/kg. 
      RESULTS: An additive effect of combined alcohol and nicotine on dopamine release 
      was obtained. This effect of alcohol and nicotine was dose-dependently blocked by 
      mecamylamine pre-treatment. CONCLUSIONS: These findings further support the 
      hypothesis that an additive effect of alcohol and nicotine on the mesolimbic 
      'reward pathway' may contribute to the high incidence of smoking in alcoholics. 
      Furthermore, nicotinic antagonists can block such effects of combined alcohol and 
      nicotine.
FAU - Tizabi, Yousef
AU  - Tizabi Y
AD  - Department of Pharmacology, College of Medicine, Howard University, 520 W Street 
      NW, Washington, DC 20059, USA. ytizabi@howard.edu
FAU - Bai, Li
AU  - Bai L
FAU - Copeland, Robert L Jr
AU  - Copeland RL Jr
FAU - Taylor, Robert E
AU  - Taylor RE
LA  - eng
GR  - 2SO6 GM 08016-36/GM/NIGMS NIH HHS/United States
GR  - P20 AA 014643/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070808
PL  - England
TA  - Alcohol Alcohol
JT  - Alcohol and alcoholism (Oxford, Oxfordshire)
JID - 8310684
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Nicotinic Agonists)
RN  - 0 (Nicotinic Antagonists)
RN  - 3K9958V90M (Ethanol)
RN  - 6EE945D3OK (Mecamylamine)
RN  - 6M3C89ZY6R (Nicotine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Central Nervous System Depressants/*pharmacology
MH  - Dopamine/*metabolism
MH  - Drug Interactions
MH  - Ethanol/*pharmacology
MH  - Extracellular Space/drug effects/metabolism
MH  - Male
MH  - Mecamylamine/pharmacology
MH  - Microdialysis
MH  - Nicotine/*pharmacology
MH  - Nicotinic Agonists/*pharmacology
MH  - Nicotinic Antagonists/pharmacology
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2007/08/10 09:00
MHDA- 2008/01/03 09:00
CRDT- 2007/08/10 09:00
PHST- 2007/08/10 09:00 [pubmed]
PHST- 2008/01/03 09:00 [medline]
PHST- 2007/08/10 09:00 [entrez]
AID - agm057 [pii]
AID - 10.1093/alcalc/agm057 [doi]
PST - ppublish
SO  - Alcohol Alcohol. 2007 Sep-Oct;42(5):413-6. doi: 10.1093/alcalc/agm057. Epub 2007 
      Aug 8.