PMID- 17687448
OWN - NLM
STAT- MEDLINE
DCOM- 20071002
LR  - 20181113
IS  - 0091-6765 (Print)
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 115
IP  - 8
DP  - 2007 Aug
TI  - Association between serum concentrations of persistent organic pollutants and 
      self-reported cardiovascular disease prevalence: results from the National Health 
      and Nutrition Examination Survey, 1999-2002.
PG  - 1204-9
AB  - BACKGROUND: There is now increasing evidence that exposure to persistent organic 
      pollutants (POPs) can contribute to the development of inflammatory diseases such 
      as atherosclerosis. OBJECTIVE: The objective of this study was to examine 
      associations of serum concentrations of POPs with self-reported history of 
      cardiovascular disease (CVD). DESIGN: Cross-sectional associations of serum POPs 
      concentrations with the prevalence of self-reported CVD were investigated in 889 
      adults >or= 40 years of age in the National Health and Nutrition Examination 
      Survey, 1999-2002. We selected 21 POPs [3 polychlorinated dibenzo-p-dioxins 
      (PCDDs), 3 polychlorinated dibenzofurans (PCDFs), 5 dioxin-like polychlorinated 
      biphenyls (PCBs), 6 nondioxin-like PCBs, and 4 organochlorine (OC) pesticides] 
      because they were detectable in >or= 60% of participants. RESULTS: Dioxin-like 
      PCBs, nondioxin-like PCBs, and OC pesticides were positively associated with the 
      prevalence of CVD only among females. Compared with those in the lowest quartile 
      of serum concentration, the odds ratios for CVD across increasing quartiles were 
      0.9, 2.0, and 5.0 for dioxin-like PCBs (p for trend < 0.01), 1.2, 1.2, and 3.8 
      for nondioxin-like PCBs (p for trend < 0.01), and 1.9, 1.7, and 4.0 for OC 
      pesticides (p for trend = 0.03). PCDDs showed positive trends with the prevalence 
      of CVD in both males and females; adjusted odds ratios were 1.4, 1.7, and 1.9 (p 
      for trend = 0.07, males and females combined). CONCLUSIONS: Our findings need to 
      be carefully interpreted because of the cross-sectional design and use of 
      self-reported CVD. Prospective studies are needed to clarify these associations.
FAU - Ha, Myung-Hwa
AU  - Ha MH
AD  - Department of Preventive Medicine and Health Promotion Research Center, School of 
      Medicine, Kyungpook National University, Daegu, Korea.
FAU - Lee, Duk-Hee
AU  - Lee DH
FAU - Jacobs, David R
AU  - Jacobs DR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Benzofurans)
RN  - 0 (Dibenzofurans, Polychlorinated)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Polychlorinated Dibenzodioxins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Benzofurans/*blood
MH  - Cardiovascular Diseases/blood/*epidemiology
MH  - Dibenzofurans, Polychlorinated
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Polychlorinated Dibenzodioxins/*analogs & derivatives/blood
MH  - Prevalence
MH  - United States/epidemiology
PMC - PMC1940073
EDAT- 2007/08/10 09:00
MHDA- 2007/10/03 09:00
PMCR- 2007/08/01
CRDT- 2007/08/10 09:00
PHST- 2007/02/21 00:00 [received]
PHST- 2007/05/25 00:00 [accepted]
PHST- 2007/08/10 09:00 [pubmed]
PHST- 2007/10/03 09:00 [medline]
PHST- 2007/08/10 09:00 [entrez]
PHST- 2007/08/01 00:00 [pmc-release]
AID - ehp0115-001204 [pii]
AID - 10.1289/ehp.10184 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2007 Aug;115(8):1204-9. doi: 10.1289/ehp.10184.