PMID- 17688264
OWN - NLM
STAT- MEDLINE
DCOM- 20080701
LR  - 20220331
IS  - 1552-4965 (Electronic)
IS  - 1549-3296 (Linking)
VI  - 85
IP  - 1
DP  - 2008 Apr
TI  - Closing capacity of segmental radius defects in rabbits.
PG  - 206-17
AB  - In the research of synthetic bone graft substitutes, the relevance for bone 
      regeneration can be confirmed in a critical-sized model. In this study the rabbit 
      radial defect was investigated as an ingenious model of critical size, due to its 
      defect immobilizing intact ulna. In addition, the influence of 
      poly(DL-lactic-co-glycolic acid) (PLGA) on bone regeneration was determined. 
      Sixteen, 4-month-old rabbits received bilateral segmental radial defects of 15 or 
      20 mm. The osteotomy ends were marked with small titanium pins. Half of the group 
      received injected PLGA microparticle/carboxymethylcellulose implants. 
      Implantation time was 12 weeks. Evaluation consisted of radiographs after surgery 
      and sacrifice, microcomputed tomography and histology. The radiographs revealed 
      that the created defects were significantly smaller after sacrifice. Further a 
      number of radii showed fibrocartilaginous interposition. Both findings indicated 
      instability of the created defect. All evaluation techniques revealed that 15 and 
      20 mm were not of critical size, as most defects were more or less regenerated. 
      PLGA microparticles did not influence bone regeneration significantly. In 
      conclusion, 15- and 20-mm radius defects in 4-month-old rabbits were not a 
      suitable model for bone regeneration as these defects were neither critical size 
      nor stable. PLGA-microparticle degradation did not influence bone regeneration.
CI  - Copyright 2007 Wiley Periodicals, Inc.
FAU - Bodde, Esther W H
AU  - Bodde EW
AD  - Department of Periodontology and Biomaterials, Radboud University, Nijmegen 
      Medical Center, Nijmegen, PO Box 9101, 6500 HB, the Netherlands.
FAU - Spauwen, Paul H M
AU  - Spauwen PH
FAU - Mikos, Antonios G
AU  - Mikos AG
FAU - Jansen, John A
AU  - Jansen JA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Bone Substitutes)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Animals
MH  - Bone Regeneration/*physiology
MH  - Bone Substitutes
MH  - Female
MH  - Lactic Acid/chemistry
MH  - Models, Animal
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Rabbits
MH  - Radius/*physiology
EDAT- 2007/08/11 09:00
MHDA- 2008/07/02 09:00
CRDT- 2007/08/11 09:00
PHST- 2007/08/11 09:00 [pubmed]
PHST- 2008/07/02 09:00 [medline]
PHST- 2007/08/11 09:00 [entrez]
AID - 10.1002/jbm.a.31549 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2008 Apr;85(1):206-17. doi: 10.1002/jbm.a.31549.