PMID- 17688413
OWN - NLM
STAT- MEDLINE
DCOM- 20071002
LR  - 20220330
IS  - 1044-5498 (Print)
IS  - 1044-5498 (Linking)
VI  - 26
IP  - 8
DP  - 2007 Aug
TI  - Genetic polymorphisms of the interleukin-18 gene and risk of prostate cancer.
PG  - 613-8
AB  - Genetic factors are known to be important in the development of prostate cancer. 
      Interleukin-18 (IL-18) is a multifunctional cytokine that induces 
      interferon-gamma secretion and plays an important role in antitumor immunity. 
      Variations in the DNA sequence in the IL-18 gene promoter may lead to altered 
      IL-18 production and/or activity, and so this can modulate an individual's 
      susceptibility to prostate cancer. To test this hypothesis, we investigated the 
      relationship of IL-18 gene promoter -137 G/C and -607 C/A polymorphisms and their 
      haplotypes with the risk of prostate cancer. We analyzed two single nucleotide 
      polymorphisms of IL-18 gene promoter -137 G/C and -607 C/A in 265 patients with 
      prostate cancer and 280 age- and sex-matched controls, using sequence-specific 
      primers-polymerase chain reaction strategy. There were significant differences in 
      the genotype and allele distribution of -137 G/C polymorphism of the IL-18 gene 
      among cases and controls. The -137 GC and CC genotypes were associated with a 
      significantly increased risk of prostate cancer as compared with the -137 GG 
      genotypes [odds ratio (OR) = 1.721; 95% confidence interval (CI): 1.187-2.496; p 
      = 0.004, and OR = 2.181; 95% CI: 1.034-4.603; p = 0.037, for GC and CC, 
      respectively]. Consistent with the results of the genotyping analyses, the 
      -137C/-607A haplotype was associated with a significantly increased risk of 
      prostate cancer as compared with the -137G/-607C haplotype (OR = 1.544; 95% CI, 
      1.137-2.096; p = 0.005). This study shows for the first time an association 
      between IL-18 gene promoter -137 G/C polymorphism and prostate cancer in a 
      Chinese population.
FAU - Liu, Yunguang
AU  - Liu Y
AD  - Department of Scientific Research, Youjiang Medical College for Nationalities, 
      Baise, Guangxi, People's Republic of China. liuyunguang07@163.com
FAU - Lin, Na
AU  - Lin N
FAU - Huang, Li
AU  - Huang L
FAU - Xu, Qunqing
AU  - Xu Q
FAU - Pang, Guangfu
AU  - Pang G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Aged
MH  - China/epidemiology
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Prostatic Neoplasms/epidemiology/*genetics
MH  - Risk Factors
EDAT- 2007/08/11 09:00
MHDA- 2007/10/03 09:00
CRDT- 2007/08/11 09:00
PHST- 2007/08/11 09:00 [pubmed]
PHST- 2007/10/03 09:00 [medline]
PHST- 2007/08/11 09:00 [entrez]
AID - 10.1089/dna.2007.0600 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2007 Aug;26(8):613-8. doi: 10.1089/dna.2007.0600.