PMID- 17688616
OWN - NLM
STAT- MEDLINE
DCOM- 20071011
LR  - 20220321
IS  - 1341-8076 (Print)
IS  - 1341-8076 (Linking)
VI  - 33
IP  - 4
DP  - 2007 Aug
TI  - Cytokine profiles in serum and peritoneal fluid from infertile women with and 
      without endometriosis.
PG  - 490-5
AB  - OBJECTIVE: To study the serum and peritoneal fluid cytokine profiles in infertile 
      women with minimal/mild active endometriosis. METHODS: Fifty-seven consecutive 
      infertile women undergoing laparoscopy for unexplained infertility had peritoneal 
      fluid and serum samples obtained at the time of laparoscopy. The levels of 
      interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-1 beta (IL-1 beta), 
      vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha 
      (TNF-alpha), monocyte chemotatic protein-1 (MCP-1), RANTES, platelet derived 
      growth factor (PDGF), soluble Fas (sFas), and soluble Fas Ligand (sFasL) in 
      peritoneal fluid and serum were measured to compare the concentration in both 
      biological fluids, in women who have minimal/mild red endometriosis using women 
      with no endometriosis as controls. RESULTS: Peritoneal fluid levels of MCP-1, 
      IL-8 and IL-6 were significantly higher in the endometriosis group (P < 0.012, P 
      = 0.003, and P = 0.015, respectively). There was no significant difference in the 
      peritoneal fluid levels of IL-1 beta, TNF-alpha, RANTES, VEGF, PDGF, sFas and 
      sFasL in the two groups. Although serum levels of IL-8 were higher in women with 
      endometriosis, the difference was not significant (P = 0.07). Serum levels of 
      PDGF, IL-6, RANTES, IL-1 beta, TNF-alpha, and sFas, were not significantly 
      different in the two groups. CONCLUSION: The elevated levels of MCP-1, IL-6, and 
      IL-8 in peritoneal fluid but not serum may indicate the importance of local 
      macrophage activating factors in the pathogenesis of endometriosis.
FAU - Kalu, Emmanuel
AU  - Kalu E
AD  - Assisted Conception Unit, St Helier Hospital, Carshalton, Surrey, UK.
FAU - Sumar, Nazira
AU  - Sumar N
FAU - Giannopoulos, Theodoros
AU  - Giannopoulos T
FAU - Patel, Pinika
AU  - Patel P
FAU - Croucher, Carolyn
AU  - Croucher C
FAU - Sherriff, Elizabeth
AU  - Sherriff E
FAU - Bansal, Amolak
AU  - Bansal A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (Cytokines)
SB  - IM
MH  - Ascitic Fluid/chemistry/*immunology
MH  - Cytokines/blood/*metabolism
MH  - Endometriosis/*immunology
MH  - Female
MH  - Humans
MH  - Immunoassay
MH  - Infertility/blood/*immunology
MH  - Statistics, Nonparametric
EDAT- 2007/08/11 09:00
MHDA- 2007/10/12 09:00
CRDT- 2007/08/11 09:00
PHST- 2007/08/11 09:00 [pubmed]
PHST- 2007/10/12 09:00 [medline]
PHST- 2007/08/11 09:00 [entrez]
AID - JOG569 [pii]
AID - 10.1111/j.1447-0756.2007.00569.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2007 Aug;33(4):490-5. doi: 
      10.1111/j.1447-0756.2007.00569.x.