PMID- 17690402
OWN - NLM
STAT- MEDLINE
DCOM- 20071002
LR  - 20131121
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 77
IP  - 2
DP  - 2007 Aug
TI  - Implications of dynamic changes among tumor necrosis factor-alpha (TNF-alpha), 
      membrane TNF receptor, and soluble TNF receptor levels in regard to the severity 
      of dengue infection.
PG  - 297-302
AB  - Tumor necrosis factor-alpha (TNF-alpha) and soluble TNF receptors (sTNFR1 and 
      sTNFR2) have been implicated in infectious diseases. We investigated dynamic 
      changes among TNF-alpha, membrane TNF receptors (mTNFR1 and mTNFR2), and sTNFR1 
      and sTNFR2 levels for patients with dengue hemorrhagic fever (DHF) and those not 
      infected during a DEN-2 outbreak in southern Taiwan in 2002-2003. Patients with 
      DHF showed the lowest levels of mTNFR1 and mTNFR2 expression. Multivariate 
      analysis showed that a decrease in levels of mTNFR1 expression was the only 
      factor significantly different between patients with DHF and those with dengue 
      fever. Moreover, lower mTNFR1 expression was significantly correlated with higher 
      plasma TNF-alpha levels, but not with sTNFR1 levels in patients with DHF. This 
      finding suggests that a lower level of mTNFR1 expression in response to a higher 
      plasma TNF-alpha level may be a pathogenic marker for early detection of DHF.
FAU - Wang, Lin
AU  - Wang L
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University College of 
      Medicine, Kaohsiung, Taiwan, Republic of China. wanglin@adm.cgmh.org.tw
FAU - Chen, Rong-Fu
AU  - Chen RF
FAU - Liu, Jien-Wei
AU  - Liu JW
FAU - Yu, Hong-Ren
AU  - Yu HR
FAU - Kuo, Ho-Chang
AU  - Kuo HC
FAU - Yang, Kuender D
AU  - Yang KD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Case-Control Studies
MH  - *Dengue Virus
MH  - Female
MH  - Flow Cytometry
MH  - Granulocytes/metabolism/virology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Receptors, Tumor Necrosis Factor, Type I/*biosynthesis/blood
MH  - Receptors, Tumor Necrosis Factor, Type II/*biosynthesis/blood
MH  - Severe Dengue/blood/*metabolism/virology
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/blood
EDAT- 2007/08/11 09:00
MHDA- 2007/10/03 09:00
CRDT- 2007/08/11 09:00
PHST- 2007/08/11 09:00 [pubmed]
PHST- 2007/10/03 09:00 [medline]
PHST- 2007/08/11 09:00 [entrez]
AID - 77/2/297 [pii]
PST - ppublish
SO  - Am J Trop Med Hyg. 2007 Aug;77(2):297-302.