PMID- 17690552
OWN - NLM
STAT- MEDLINE
DCOM- 20071029
LR  - 20220331
IS  - 1420-8008 (Print)
IS  - 1420-8008 (Linking)
VI  - 24
IP  - 3
DP  - 2007
TI  - Role of serotonin transporter polymorphisms in the behavioural and psychological 
      symptoms in probable Alzheimer disease patients.
PG  - 201-6
AB  - BACKGROUND/AIMS: Alzheimer disease (AD) patients commonly suffer from behavioural 
      and psychological symptoms of dementia (BPSD). A genetic component to BPSD 
      development in AD has been demonstrated. This is an investigation of whether the 
      linked polymorphic region and variable number tandem repeat variants of the 
      serotonin transporter (SERT) are associated with BPSD. METHODS: The longitudinal 
      measures of BPSD of our large cohort of 367 AD patients were assessed by the 
      Neuropsychiatric Inventory. Measures with good evidence of serotonergic 
      involvement (delusions, hallucinations, depression, anxiety, agitation/aggression 
      and irritability) were related to genotype and allele frequencies of the linked 
      polymorphic region and variable number tandem repeat variants. RESULTS: Analysis 
      revealed significant relationships between the linked polymorphic region variant 
      long allele with irritability and the variable number tandem repeat 10-repeat 
      allele with psychosis, but no associations were found with depression, anxiety or 
      agitation/aggression. CONCLUSION: Our data and review of previous studies suggest 
      SERT could play a minor role in development of psychosis and aggressive/irritable 
      tendencies; however, further investigations are required in large, 
      well-characterized cohorts.
CI  - 2007 S. Karger AG, Basel
FAU - Pritchard, Antonia L
AU  - Pritchard AL
AD  - Molecular Psychiatry Group, Queensland Institute of Medical Research, Herston, 
      Brisbane, Australia. Antonia.Pritchard@qimr.edu.au
FAU - Pritchard, Colin W
AU  - Pritchard CW
FAU - Bentham, Peter
AU  - Bentham P
FAU - Lendon, Corinne L
AU  - Lendon CL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070810
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Age Factors
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/*genetics/*psychology
MH  - Behavior/*physiology
MH  - Cohort Studies
MH  - Female
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Minisatellite Repeats/genetics
MH  - Neuropsychological Tests
MH  - Polymorphism, Genetic/*genetics
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Sex Factors
EDAT- 2007/08/11 09:00
MHDA- 2007/10/30 09:00
CRDT- 2007/08/11 09:00
PHST- 2007/04/27 00:00 [accepted]
PHST- 2007/08/11 09:00 [pubmed]
PHST- 2007/10/30 09:00 [medline]
PHST- 2007/08/11 09:00 [entrez]
AID - 000107081 [pii]
AID - 10.1159/000107081 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2007;24(3):201-6. doi: 10.1159/000107081. Epub 2007 
      Aug 10.