PMID- 17691221
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20231208
IS  - 0065-1400 (Print)
IS  - 0065-1400 (Linking)
VI  - 67
IP  - 2
DP  - 2007
TI  - Erythropoietin preconditioning suppresses neuronal death following status 
      epilepticus in rats.
PG  - 141-8
LID - 1641 [pii]
LID - 10.55782/ane-2007-1641 [doi]
AB  - Status epilepticus (SE) is a grave condition in which the brain undergoes lasting 
      seizures which can lead to neuronal loss. Our previous study suggested that 
      preconditioning with erythropoietin (Epo) suppressed neuronal apoptosis in 
      hippocampus of rats following SE in vivo by inhibiting caspase-3. In this study, 
      we investigated the mechanisms by which Epo preconditioning may exert its 
      anti-apoptotic effects using a lithium-pilocarpine induced SE model in rats. The 
      effects of Epo on neuronal cell death were evaluated using terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), and the 
      role of the Bcl-2 protein family, which have been shown to be anti- (Bcl-2, 
      Bcl-w) or pro- (Bid, Bim) apoptotic, was examined with immunofluorescence. We 
      found Epo preconditioning decreased the total number of TUNEL, Bim and Bid 
      positive cells, but increased the total number of Bcl-w and Bcl-2 positive cells. 
      These results suggest that systemic Epo pretreatment protects neurons in an acute 
      phase of SE and may result in further suppression of neuronal apoptosis in 
      hippocampus by regulating the balance between pro- and anti-apoptotic Bcl-2 
      family proteins.
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Neurology, Xijing Hospital, The Fourth Military Medical University, 
      Xi'an 710032, China.
FAU - Huang, YuanGui
AU  - Huang Y
FAU - Yu, Xin
AU  - Yu X
FAU - Sun, Hong
AU  - Sun H
FAU - Li, YongNan
AU  - Li Y
FAU - Deng, YanChun
AU  - Deng Y
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (BH3 Interacting Domain Death Agonist Protein)
RN  - 0 (Bcl-2-Like Protein 11)
RN  - 0 (Bcl2l11 protein, rat)
RN  - 0 (Indoles)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - 11096-26-7 (Erythropoietin)
RN  - 47165-04-8 (DAPI)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Apoptosis Regulatory Proteins/metabolism
MH  - BH3 Interacting Domain Death Agonist Protein/metabolism
MH  - Bcl-2-Like Protein 11
MH  - Cell Count
MH  - Cell Death/drug effects
MH  - Disease Models, Animal
MH  - Drug Interactions
MH  - Erythropoietin/*administration & dosage
MH  - In Situ Nick-End Labeling/methods
MH  - Indoles
MH  - Male
MH  - Membrane Proteins/metabolism
MH  - Neurons/*drug effects/metabolism
MH  - Neuroprotective Agents/*administration & dosage
MH  - Pilocarpine
MH  - Proto-Oncogene Proteins/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Status Epilepticus/chemically induced/*pathology/*prevention & control
EDAT- 2007/08/19 09:00
MHDA- 2007/09/27 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
AID - 1641 [pii]
AID - 10.55782/ane-2007-1641 [doi]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 2007;67(2):141-8. doi: 10.55782/ane-2007-1641.