PMID- 17692569
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20070917
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 28
IP  - 9
DP  - 2007 Sep
TI  - Dendritic cell-endothelial cell cross-talk in angiogenesis.
PG  - 385-92
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that have a 
      pivotal role in the onset and regulation of adaptive immune responses. DCs have 
      the ability to regulate inflammation through their capacity to release cytokines 
      and chemokines and kill pathogens, which they share with other phagocytes. Recent 
      observations have shown that different DC subsets produce and release various 
      pro- and anti-angiogenic mediators depending on their activation status and 
      cytokine milieu. In particular, alternatively activated DCs exert a potent 
      pro-angiogenic activity that is mediated by the prototypic angiogenic growth 
      factor vascular endothelial growth factor-A (VEGF-A). In turn, pro- and 
      anti-angiogenic mediators can affect the biology of DCs, modulating their 
      differentiation and maturation. Finally, DCs can trans-differentiate into 
      endothelial-like cells, possibly contributing to vasculogenesis in the adult. 
      Thus, DCs might exert an important impact on the neovascularization process in 
      different physiopathological conditions.
FAU - Sozzani, Silvano
AU  - Sozzani S
AD  - Unit of General Pathology and Immunology, Department of Biomedical Sciences and 
      Biotechnology, University of Brescia, Viale Europa 11, 25123 Brescia, Italy. 
      sozzani@med.unibs.it
FAU - Rusnati, Marco
AU  - Rusnati M
FAU - Riboldi, Elena
AU  - Riboldi E
FAU - Mitola, Stefania
AU  - Mitola S
FAU - Presta, Marco
AU  - Presta M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070810
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - Animals
MH  - Cell Communication/*immunology
MH  - Dendritic Cells/*immunology/metabolism
MH  - Endothelial Cells/*immunology/metabolism
MH  - Humans
MH  - Neovascularization, Pathologic/*immunology/metabolism
RF  - 89
EDAT- 2007/08/19 09:00
MHDA- 2007/12/21 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/04/22 00:00 [received]
PHST- 2007/06/25 00:00 [revised]
PHST- 2007/07/31 00:00 [accepted]
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
AID - S1471-4906(07)00185-8 [pii]
AID - 10.1016/j.it.2007.07.006 [doi]
PST - ppublish
SO  - Trends Immunol. 2007 Sep;28(9):385-92. doi: 10.1016/j.it.2007.07.006. Epub 2007 
      Aug 10.