PMID- 17692920
OWN - NLM
STAT- MEDLINE
DCOM- 20080207
LR  - 20140325
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 28
IP  - 6
DP  - 2007 Nov
TI  - Repeated intermittent MDMA binges reduce DAT density in mice and SERT density in 
      rats in reward regions of the adolescent brain.
PG  - 1158-69
AB  - The popular recreational drug, 3,4-methylenedioxymethamphetamine (MDMA) is often 
      taken as intermittent binges by adolescents at dance clubs. The neurobiological 
      mechanisms that underlie MDMA-induced psychiatric conditions are still poorly 
      understood. In the present study, mimicking adolescent patterns of 
      administration, repeated intermittent MDMA binges (3x5 mg/(kg day) given 3h 
      apart, every 7th day for 4 weeks) were given to adolescent mice and rats. 
      Behavioral responses in the open-field and autoradiographic ligand-binding to 
      dopamine (DAT) and serotonin (SERT) transporters in reward regions of the brain 
      were measured. In the open-field, total horizontal activity (HA) was 
      significantly increased in both mice and rats following the first and third 
      weekly administered MDMA binge. However, rats, but not mice, exhibited an 
      enhanced activity in the centre of the open-field arena, indicating on reduced 
      anxiety or enhanced impulsivity, which is known to be associated with altered 
      serotonin activity. Specific binding of DAT, but not SERT, was significantly 
      reduced in the mouse AcbSh and CPU using in vitro autoradiography. On the 
      contrary, SERT, but not DAT density was significantly reduced in the AcbSh of 
      rats. Taken together, our data provide evidence for differential regulation of 
      DAT and SERT densities in reward-related brain regions of rats and mice after 
      long-term intermittent administration of MDMA.
FAU - Kindlundh-Hogberg, Anna M S
AU  - Kindlundh-Hogberg AM
AD  - Section of Translational Neuropharmacology, Department of Physiology and 
      Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, 171 77 Stockholm, 
      Sweden. Anna.Kindlundh@fyfa.ki.se
FAU - Schioth, Helgi B
AU  - Schioth HB
FAU - Svenningsson, Per
AU  - Svenningsson P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070710
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Age Factors
MH  - Aging/*metabolism
MH  - Animals
MH  - Autoradiography
MH  - Behavior, Animal/*drug effects
MH  - Brain/*drug effects/metabolism/pathology
MH  - Central Nervous System Stimulants/administration & dosage/*toxicity
MH  - Dopamine Plasma Membrane Transport Proteins/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Down-Regulation
MH  - Drug Administration Schedule
MH  - Exploratory Behavior/drug effects
MH  - Impulsive Behavior
MH  - Locomotion/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Reward
MH  - Serotonin Plasma Membrane Transport Proteins/*metabolism
MH  - Species Specificity
MH  - Time Factors
EDAT- 2007/08/19 09:00
MHDA- 2008/02/08 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/03/16 00:00 [received]
PHST- 2007/06/28 00:00 [revised]
PHST- 2007/07/04 00:00 [accepted]
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2008/02/08 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
AID - S0161-813X(07)00156-8 [pii]
AID - 10.1016/j.neuro.2007.07.002 [doi]
PST - ppublish
SO  - Neurotoxicology. 2007 Nov;28(6):1158-69. doi: 10.1016/j.neuro.2007.07.002. Epub 
      2007 Jul 10.