PMID- 17693449
OWN - NLM
STAT- MEDLINE
DCOM- 20070920
LR  - 20220310
IS  - 1368-4973 (Print)
IS  - 1472-3263 (Electronic)
IS  - 1368-4973 (Linking)
VI  - 83
IP  - 5
DP  - 2007 Aug
TI  - Syphilis screening and intervention in 500,000 pregnant women in Shenzhen, the 
      People's Republic of China.
PG  - 347-50
AB  - OBJECTIVES: To understand the disease epidemiology of syphilis in pregnant women, 
      and to evaluate the effectiveness of the screening and intervention programme, 
      for the purpose of controlling mother-to-child syphilis transmission in Shenzhen, 
      in the People's Republic of China (PRC). METHODS: At the Shenzhen Center for 
      Disease Control and Prevention (SZCDC), we used the toluidine red unheated serum 
      test (TRUST) for the primary screening of pregnant women, and confirmed positive 
      results with the Treponema pallidum particle agglutination (TPPA) test. We 
      informed and treated those with positive results. For the women who chose to 
      proceed with the pregnancy, we clinically screened their babies for congenital 
      syphilis using the 19S-IgM FTA-Abs test. RESULTS: Between 1 July 2002 and 31 
      December 2005, we screened 477,656 pregnant women for syphilis, of whom 2208 
      (0.5%) tested positive. From 2003 to 2005, we collected epidemiological and 
      treatment data from 2019 positive syphilis cases. Of these, 1855 (91.9%) of the 
      pregnant women received treatment. Among the 1020 infants born to these women, 92 
      (9.0%) were confirmed to have congenital syphilis. If we exclude the mothers who 
      had syphilis positive babies without undergoing prenatal screening, the project's 
      success rate for mother-to-child transmission intervention was 99.1%. 
      CONCLUSIONS: After four years of implementation, we proved the programme to be 
      successful in preventing mother-to-child syphilis transmission. Further work 
      should be done to ensure the earlier screening and treatment of pregnant women.
FAU - Cheng, J Q
AU  - Cheng JQ
AD  - Shenzhen Center for Disease Control and Prevention, Shenzhen, China. 
      cjinquan@sohu.com
FAU - Zhou, H
AU  - Zhou H
FAU - Hong, F C
AU  - Hong FC
FAU - Zhang, D
AU  - Zhang D
FAU - Zhang, Y J
AU  - Zhang YJ
FAU - Pan, P
AU  - Pan P
FAU - Cai, Y M
AU  - Cai YM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Sex Transm Infect
JT  - Sexually transmitted infections
JID - 9805554
SB  - IM
CIN - Sex Transm Infect. 2007 Aug;83(5):345-6. PMID: 17693447
MH  - Adult
MH  - China/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infectious Disease Transmission, Vertical
MH  - Mass Screening/statistics & numerical data
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/epidemiology/*prevention & control
MH  - Pregnancy Outcome
MH  - Prenatal Diagnosis/*statistics & numerical data
MH  - Syphilis/epidemiology/*prevention & control/transmission
PMC - PMC2659022
EDAT- 2007/08/19 09:00
MHDA- 2007/09/21 09:00
PMCR- 2010/08/01
CRDT- 2007/08/19 09:00
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2007/09/21 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
PHST- 2010/08/01 00:00 [pmc-release]
AID - 83/5/347 [pii]
AID - st23655 [pii]
AID - 10.1136/sti.2006.023655 [doi]
PST - ppublish
SO  - Sex Transm Infect. 2007 Aug;83(5):347-50. doi: 10.1136/sti.2006.023655.