PMID- 17694498
OWN - NLM
STAT- MEDLINE
DCOM- 20070914
LR  - 20161124
IS  - 1506-9680 (Print)
IS  - 1506-9680 (Linking)
VI  - 10
IP  - 1
DP  - 2007
TI  - FDG-PET detection of primary bone marrow large B-cell lymphoma in a patient with 
      hairy cell leukemia.
PG  - 23-5
AB  - We describe a case of hairy cell leukaemia (HCL) coexistent with non-Hodgkin's 
      lymphoma (NHD). This combination is reported to be extremely rare with no clear 
      demonstration of the clonal relationship between the two conditions. After a 
      previous failure of purine analogue therapy, our patient was successfully treated 
      with rituximab resulting in normalisation of blood cell count cessation of blood 
      transfusion and negative iliac crest biopsy. Unfortunately, the patient developed 
      intense and persistent bone pain during the 1(st) line treatment for HCL. 
      Skeletal X-rays, neck-thorax-abdomen CT scan and repeated bone MRI were 
      unremarkable and bone scintigraphy showed non-specific changes. Laboratory 
      examinations were normal. To better evaluate bone scintigraphy results, we 
      finally performed FDG-PET/CT, which showed multiple foci of intense abnormal 
      radiotracer uptake involving the bone marrow. An FDG-PET/CT guided bone marrow 
      biopsy showed primary bone marrow diffuse large B-cell lymphoma (LBCL). Despite 
      2(nd) and 3(rd) line treatment, the patient died shortly after for central 
      nervous system involvement by NHD. The role of FDG-PET/CT in identifying bone and 
      bone marrow localization of NHD is reviewed and an earlier use is suggested in 
      poorly understood bone pain.
FAU - Paolini, Rossella
AU  - Paolini R
AD  - Onco-Haemathology Service, S.Maria della Misericordia Rovigo Hospital, Rovigo, 
      Italy.
FAU - Bianchini, Enzo
AU  - Bianchini E
FAU - D'Andrea, Emma
AU  - D'Andrea E
FAU - Al-Nahhas, Adil
AU  - Al-Nahhas A
FAU - Banti, Elena
AU  - Banti E
FAU - Muzzio, Pier Carlo
AU  - Muzzio PC
FAU - Rubello, Domenico
AU  - Rubello D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Poland
TA  - Nucl Med Rev Cent East Eur
JT  - Nuclear medicine review. Central & Eastern Europe
JID - 100886103
RN  - 0 (Fluorine Radioisotopes)
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Bone Marrow Neoplasms/diagnostic imaging
MH  - Female
MH  - *Fluorine Radioisotopes
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Leukemia, Hairy Cell/*diagnostic imaging
MH  - Lymphoma, B-Cell/*diagnostic imaging
MH  - Lymphoma, Large B-Cell, Diffuse/*diagnostic imaging
MH  - Neoplasms, Multiple Primary/*diagnostic imaging
MH  - Positron-Emission Tomography
MH  - *Radiopharmaceuticals
MH  - Tomography, X-Ray Computed
EDAT- 2007/08/21 09:00
MHDA- 2007/09/15 09:00
CRDT- 2007/08/21 09:00
PHST- 2007/08/21 09:00 [pubmed]
PHST- 2007/09/15 09:00 [medline]
PHST- 2007/08/21 09:00 [entrez]
PST - ppublish
SO  - Nucl Med Rev Cent East Eur. 2007;10(1):23-5.