PMID- 17697403
OWN - NLM
STAT- MEDLINE
DCOM- 20080404
LR  - 20131121
IS  - 0007-1145 (Print)
IS  - 0007-1145 (Linking)
VI  - 99
IP  - 3
DP  - 2008 Mar
TI  - Effect of folic acid on prenatal alcohol-induced modification of brain proteome 
      in mice.
PG  - 455-61
AB  - Maternal alcohol consumption during pregnancy can induce central nervous system 
      abnormalities in the fetus, and folic acid supplementation can reverse some of 
      the effects. The objective of the present study was to investigate prenatal 
      alcohol exposure-induced fetal brain proteome alteration and the protective 
      effect of folic acid using proteomic techniques. Alcohol (5.0 g/kg) was given 
      intragastrically from gestational day (GD) 6 to 15, with or without 60.0 mg folic 
      acid/kg given intragastrically during GD 1-16 to pregnant Balb/c mice. The 
      control group received distilled water only. Results of litter evaluation on GD 
      18 showed that supplementation of folic acid reversed the prevalence of 
      microcephaly induced by alcohol. Proteomic analysis indicated that, under the 
      dosage of the present investigation, folic acid mainly reversed the 
      alcohol-altered proteins involved in energy production, signal pathways and 
      protein translation, which are all important for central nervous system 
      development.
FAU - Xu, Yajun
AU  - Xu Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100083, China. yajun_xucn@126.com
FAU - Tang, Yunan
AU  - Tang Y
FAU - Li, Yong
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070813
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proteome)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Eating
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/metabolism/*prevention & control
MH  - Fetal Growth Retardation/metabolism/prevention & control
MH  - Folic Acid/*therapeutic use
MH  - Gene Expression Profiling/methods
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microcephaly/chemically induced/metabolism/prevention & control
MH  - Nerve Tissue Proteins/*metabolism
MH  - Pregnancy
MH  - Prenatal Care/methods
MH  - Prenatal Exposure Delayed Effects
MH  - *Prenatal Nutritional Physiological Phenomena
MH  - Proteome/*drug effects
EDAT- 2007/08/19 09:00
MHDA- 2008/04/05 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2008/04/05 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
AID - S0007114507812074 [pii]
AID - 10.1017/S0007114507812074 [doi]
PST - ppublish
SO  - Br J Nutr. 2008 Mar;99(3):455-61. doi: 10.1017/S0007114507812074. Epub 2007 Aug 
      13.