PMID- 17697439 OWN - NLM STAT- MEDLINE DCOM- 20080424 LR - 20161020 IS - 1041-6102 (Print) IS - 1041-6102 (Linking) VI - 20 IP - 1 DP - 2008 Feb TI - Profiles of matrix metalloproteinases and their inhibitors in plasma of patients with dementia. PG - 67-76 AB - BACKGROUND: Matrix metalloproteinases (MMPs) are elevated in the brain tissue of patients with dementia and may play a role in the pathophysiology of dementia. MMP-9 and tissue inhibitors of MMPs (TIMPs) are elevated in postmortem brain tissue of patients with Alzheimer's disease (AD). In a previous study we showed that circulating levels of MMP-9 are elevated in AD patients. The aim of the present study was to examine circulating levels of MMP-1, MMP-2, MMP-9, TIMP-1 and TIMP-2 in the plasma of patients with mild cognitive impairment (MCI), AD, vascular dementia (VaD), dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD), to determine, whether plasma profiles of MMPs and TIMPs differ in various types of dementia. METHODS: Gelatinolytic activity (MMP-2 and MMP-9) was measured in all plasma samples by zymography. Levels of MMP-2, MMP-9, MMP-1 as well as TIMP-1 and TIMP-2 were measured by ELISA. RESULTS: We found constitutive expression of MMP-1, -2 and -9 as well as TIMP-1 and -2 in all the samples investigated. As shown previously, MMP-9 was significantly elevated in the plasma of AD patients (p = 0.004) as compared to controls and MCI patients. Plasma levels of TIMP-1 were significantly lower in VD samples as compared to all other groups. Levels of TIMP-2 were significantly lower in patients with FTD as compared to AD, VaD and MCI patients. There were no significant changes of MMP-1 and MMP-2 levels in the samples. CONCLUSION: These findings suggest that circulating levels of MMP-9, TIMP-1 and TIMP-2 and changes in the MMP/TIMP balance in plasma differ in various types of dementia. FAU - Lorenzl, Stefan AU - Lorenzl S AD - Department of Neurology and Neurosience, Weill Medical College of Cornell University, New York, USA. Stefan.Lorenzl@med.uni-muenchen.de FAU - Buerger, Katharina AU - Buerger K FAU - Hampel, Harald AU - Hampel H FAU - Beal, M Flint AU - Beal MF LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20070815 PL - England TA - Int Psychogeriatr JT - International psychogeriatrics JID - 9007918 RN - 0 (Tissue Inhibitor of Metalloproteinase-1) RN - 0 (Tissue Inhibitor of Metalloproteinases) RN - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2) RN - EC 3.4.24.- (Matrix Metalloproteinases) RN - EC 3.4.24.24 (Matrix Metalloproteinase 2) RN - EC 3.4.24.35 (Matrix Metalloproteinase 9) RN - EC 3.4.24.7 (Matrix Metalloproteinase 1) SB - IM MH - Aged MH - Alzheimer Disease/enzymology MH - Cognition Disorders/diagnosis/*enzymology MH - Dementia/diagnosis/*enzymology MH - Dementia, Vascular/diagnosis/enzymology MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Humans MH - Lewy Body Disease/diagnosis/enzymology MH - Male MH - Matrix Metalloproteinase 1/blood MH - Matrix Metalloproteinase 2/blood MH - Matrix Metalloproteinase 9/blood MH - Matrix Metalloproteinases/*blood MH - Memory Disorders/diagnosis/enzymology MH - Middle Aged MH - Neuropsychological Tests MH - Pick Disease of the Brain/diagnosis/enzymology MH - Plasma/chemistry MH - Severity of Illness Index MH - Tissue Inhibitor of Metalloproteinase-1/blood MH - Tissue Inhibitor of Metalloproteinase-2/blood MH - Tissue Inhibitor of Metalloproteinases/*blood EDAT- 2007/08/19 09:00 MHDA- 2008/04/25 09:00 CRDT- 2007/08/19 09:00 PHST- 2007/08/19 09:00 [pubmed] PHST- 2008/04/25 09:00 [medline] PHST- 2007/08/19 09:00 [entrez] AID - S1041610207005790 [pii] AID - 10.1017/S1041610207005790 [doi] PST - ppublish SO - Int Psychogeriatr. 2008 Feb;20(1):67-76. doi: 10.1017/S1041610207005790. Epub 2007 Aug 15.