PMID- 17697600
OWN - NLM
STAT- MEDLINE
DCOM- 20081010
LR  - 20070816
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 42
IP  - 6
DP  - 2007 Jun
TI  - [Study of the mechanism of mast cell increase in cellular leiomyoma of uterus].
PG  - 390-3
AB  - OBJECTIVE: To study the mechanism of mast cell increase in cellular leiomyoma of 
      uterus. METHODS: Tissue sections from 30 cases of cellular leiomyoma of uterus, 
      15 cases of leiomyosarcoma and 30 cases of ordinary leiomyoma were studied using 
      immunohistochemical double labeling techniques. The expression of mast cell 
      tryptase and Ki-67 as well as mast cell tryptase and chemotactic factors RANTES, 
      Eotaxin, monocyte chemoattractant protein-1 (MCP-1), transforming growth 
      factor-beta (TGF-beta) were double immunostained. RESULTS: Ki-67 in mast cells 
      was rarely expressed in each group. Expressions of regulate upon activation 
      normal T cell expressed and secreted (RANTES), Eotaxin and TGF -beta in cellular 
      leiomyoma were 78%, 89%, 91%, respectively. They were all higher than those in 
      ordinary leiomyoma and leiomyosarcoma (P < 0.01), which were 60%, 81%, 86% and 
      39%, 44%, 59%, respectively. There were positive correlations between RANTES and 
      the number of mast cells (r = 0.655, P < 0.01) as well as between Eotaxin and the 
      number of mast cells (r = 0.543, P < 0.01). However, expression of MCP-1 was not 
      observed in tumor cells in any group. CONCLUSIONS: Mast cell increase in cellular 
      leiomyoma of the uterus is due to local recruitment of mast cells. RANTES and 
      Eotaxin secreted by smooth muscle tumor cells correlates with the recruitment of 
      mast cells, but MCP-1 and TGF-beta do not.
FAU - Lu, Jie-Qiang
AU  - Lu JQ
AD  - Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou 
      Medical College, Wenzhou 325027, China.
FAU - Zhu, Xue-Qiong
AU  - Zhu XQ
FAU - Dong, Ke
AU  - Dong K
FAU - Xiang, Mei
AU  - Xiang M
FAU - Lin, Yi
AU  - Lin Y
FAU - Hu, Yue
AU  - Hu Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Ki-67 Antigen)
SB  - IM
MH  - Adult
MH  - Cell Count
MH  - Chemokine CCL2/biosynthesis
MH  - Chemokine CCL5/biosynthesis
MH  - Chemotactic Factors/*biosynthesis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/biosynthesis
MH  - Leiomyoma/*metabolism/pathology
MH  - Leiomyosarcoma/metabolism/pathology
MH  - Mast Cells/*metabolism/pathology
MH  - Middle Aged
MH  - Uterine Neoplasms/*metabolism/pathology
EDAT- 2007/08/19 09:00
MHDA- 2008/10/11 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2008/10/11 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2007 Jun;42(6):390-3.