PMID- 17698045
OWN - NLM
STAT- MEDLINE
DCOM- 20071214
LR  - 20131121
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1169
DP  - 2007 Sep 12
TI  - Behavioral alteration in the adult rats prenatally exposed to 
      para-chlorophenylalanine.
PG  - 9-16
AB  - In the present work, effects of maternal administration of 
      para-chlorophenylalanine (PCPA), a serotonin synthesis inhibitor, on behavior of 
      adult offspring were studied. Pregnant rats were injected intraperitoneally with 
      PCPA (200/100/100/50 mg/kg) either on the gestational days (GD) 8-11 or 14-17, or 
      with vehicle at the same days. Behavioral parameters, in an open field, the 
      Porsolt forced swim test and the Morris water maze test were evaluated at the age 
      of 3-3.5 months in the male and female offspring. The prenatal PCPA increased 
      activity in an open field in the offspring treated on either GD 8-11 or 14-17. 
      The highest levels of the activity were revealed in the male and female offspring 
      treated on GD 14-17. Besides, the PCPA treatment on GD 8-11 or 14-17 facilitated 
      the intersession habituation of activity to repeated exposures to an open field 
      in the male offspring. Both male and female offspring treated on GD 14-17 showed 
      an increased immobility in the Porsolt forced swim test and a significant 
      learning impairment in the Morris water maze. Thus, it has been shown that 
      administration of PCPA to pregnant rats might cause significant changes in the 
      adult offspring behavior. These results provide further evidence that unfavorable 
      influence may have more adverse effects on the behavioral development of rats 
      when exposed during the final trimester of pregnancy than during the second 
      trimester.
FAU - Vataeva, Ludmila A
AU  - Vataeva LA
AD  - Laboratory of Ontogenesis of the Nervous System, Pavlov Institute of Physiology 
      of the Russian Academy of Sciences, Nab. Makarova, 6, St. Petersburg 199034, 
      Russia. vataeva@yandex.ru
FAU - Kudrin, Vladimir S
AU  - Kudrin VS
FAU - Vershinina, Elena A
AU  - Vershinina EA
FAU - Mosin, Vjacheslav M
AU  - Mosin VM
FAU - Tiul'kova, Ekaterina I
AU  - Tiul'kova EI
FAU - Otellin, Vladimir A
AU  - Otellin VA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070713
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Serotonin Antagonists)
RN  - 333DO1RDJY (Serotonin)
RN  - R5J7E3L9SP (Fenclonine)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Avoidance Learning/drug effects/physiology
MH  - Behavior, Animal/*drug effects/physiology
MH  - Brain/*drug effects/*growth & development/physiopathology
MH  - Brain Chemistry/drug effects/physiology
MH  - Exploratory Behavior/drug effects/physiology
MH  - Female
MH  - Fenclonine/*adverse effects
MH  - Habituation, Psychophysiologic/drug effects/physiology
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/physiopathology
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/deficiency
MH  - Serotonin Antagonists/adverse effects
MH  - Sex Characteristics
MH  - Stress, Physiological/metabolism/physiopathology
MH  - *Time
EDAT- 2007/08/19 09:00
MHDA- 2007/12/15 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/01/31 00:00 [received]
PHST- 2007/06/02 00:00 [revised]
PHST- 2007/06/22 00:00 [accepted]
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2007/12/15 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
AID - S0006-8993(07)01545-4 [pii]
AID - 10.1016/j.brainres.2007.06.056 [doi]
PST - ppublish
SO  - Brain Res. 2007 Sep 12;1169:9-16. doi: 10.1016/j.brainres.2007.06.056. Epub 2007 
      Jul 13.