PMID- 17698214
OWN - NLM
STAT- MEDLINE
DCOM- 20080515
LR  - 20191210
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 146
IP  - 1-3
DP  - 2008 Feb 7
TI  - Hippocampal MMP-3 elevation is associated with passive avoidance conditioning.
PG  - 19-25
AB  - Alterations in synaptic efficiency that underlie learning and memory 
      consolidation appear to require an accompanying reconfiguration of the 
      extracellular matrix (ECM). This restructuring of the ECM is carried out, in 
      part, by a family of enzymes called, the matrix metalloproteinases, which 
      includes matrix metalloproteinase-3 (MMP-3: stromelysin-1). The present study 
      determined that a transient elevation in hippocampal MMP-3 expression occurred in 
      rats following associative learning in the passive avoidance (PA) task. No change 
      in MMP-3 was observed when rats were exposed either to the behavioral apparatus 
      or the training stimulus alone. Furthermore, when an MMP-3 inhibitor was 
      administered prior to PA training, dose-dependent learning deficits were 
      observed, suggesting a causal relationship between learning-induced hippocampal 
      MMP-3 elevation and associative memory formation. These findings suggest that 
      increased hippocampal MMP-3 expression is an event that may play an important 
      role in synaptic plasticity and memory consolidation.
FAU - Olson, Mikel L
AU  - Olson ML
AD  - Department of Psychology, Washington State University, Pullman, WA 99164-4820, 
      USA. molson@cord.edu
FAU - Meighan, Peter C
AU  - Meighan PC
FAU - Brown, Travis E
AU  - Brown TE
FAU - Asay, Aaron L
AU  - Asay AL
FAU - Benoist, Caroline C
AU  - Benoist CC
FAU - Harding, Joseph W
AU  - Harding JW
FAU - Wright, John W
AU  - Wright JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070719
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - *Avoidance Learning
MH  - *Conditioning, Psychological
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Matrix Metalloproteinase 3/*metabolism
MH  - *Models, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Up-Regulation
EDAT- 2007/08/19 09:00
MHDA- 2008/05/16 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/06/22 00:00 [received]
PHST- 2007/07/02 00:00 [accepted]
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2008/05/16 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
AID - S0167-0115(07)00131-0 [pii]
AID - 10.1016/j.regpep.2007.07.004 [doi]
PST - ppublish
SO  - Regul Pept. 2008 Feb 7;146(1-3):19-25. doi: 10.1016/j.regpep.2007.07.004. Epub 
      2007 Jul 19.