PMID- 1769922
OWN - NLM
STAT- MEDLINE
DCOM- 19920224
LR  - 20190820
IS  - 0378-5955 (Print)
IS  - 0378-5955 (Linking)
VI  - 56
IP  - 1-2
DP  - 1991 Nov
TI  - Radial communication between the perilymphatic scalae of the cochlea. I: 
      Estimation by tracer perfusion.
PG  - 29-36
AB  - The degree to which radial exchange between scala tympani (ST) and scala 
      vestibuli (SV) can occur has not previously been quantified. We have measured the 
      amount of cross-communication in the third turn of the guinea pig cochlea using 
      an ionic tracer, trimethylphenylammonium (TMPA). TMPA was perfused through one 
      scala while TMPA concentrations were measured simultaneously in the perfused and 
      non-perfused scalae. On the basis of the time course of TMPA increase recorded in 
      the non-perfused scala, we were able to calculate rate constants for cross-leak 
      and clearance. Cross-leak in the third turn occurred remarkably rapidly with a 
      rate constant from ST to SV of 0.049 min-1 and from SV to ST of 0.031 min-1. 
      These correspond to transfer half times of 14.2 and 22.4 min respectively. This 
      result demonstrates that ST and SV in the third turn cannot be regarded as 
      independent compartments.
FAU - Salt, A N
AU  - Salt AN
AD  - Department of Otolaryngology, Washington University School of Medicine, St. 
      Louis, Missouri 63110.
FAU - Ohyama, K
AU  - Ohyama K
FAU - Thalmann, R
AU  - Thalmann R
LA  - eng
GR  - DC00384/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 3426-74-2 (phenyltrimethylammonium)
SB  - IM
MH  - Animals
MH  - Cochlea/anatomy & histology/*physiology
MH  - Diffusion
MH  - Guinea Pigs
MH  - Perfusion
MH  - Perilymph/*physiology
MH  - Quaternary Ammonium Compounds/pharmacokinetics
MH  - Scala Tympani/physiology
MH  - Vestibule, Labyrinth/physiology
EDAT- 1991/11/01 00:00
MHDA- 1991/11/01 00:01
CRDT- 1991/11/01 00:00
PHST- 1991/11/01 00:00 [pubmed]
PHST- 1991/11/01 00:01 [medline]
PHST- 1991/11/01 00:00 [entrez]
AID - 0378-5955(91)90150-8 [pii]
AID - 10.1016/0378-5955(91)90150-8 [doi]
PST - ppublish
SO  - Hear Res. 1991 Nov;56(1-2):29-36. doi: 10.1016/0378-5955(91)90150-8.