PMID- 17702640
OWN - NLM
STAT- MEDLINE
DCOM- 20080103
LR  - 20150813
IS  - 1359-6101 (Print)
IS  - 1359-6101 (Linking)
VI  - 18
IP  - 5-6
DP  - 2007 Oct-Dec
TI  - The role of the interferon regulatory factor (IRF) family in dendritic cell 
      development and function.
PG  - 503-10
AB  - Dendritic cells (DCs) are powerful sensors of foreign pathogens as well as cancer 
      cells and provide the first line of defence against infection. They also serve as 
      a major link between innate and adaptive immunity. Immature DCs respond to 
      incoming danger signals and undergo maturation to produce high levels of 
      proinflammatory cytokines including type I interferons (IFNs) to establish innate 
      immunity. They then present antigens to T lymphocytes to stimulate lasting 
      specific immune responses. Recent studies point to the importance of DCs in the 
      induction of peripheral tolerance. Transcription factors of the IRF family have 
      emerged as crucial controllers of many aspects of DC activity, playing an 
      essential role in the establishment of early innate immunity. Furthermore, eight 
      of the nine members of the IRF family have been shown to control either the 
      differentiation and/or the functional activities of DCs. In this review, we focus 
      on three aspects of DC properties that are under the control of IRFs: (1) the 
      development and differentiation, (2) maturation in response to toll-like receptor 
      (TLR) signalling and the production of anti-microbial cytokines, and (3) 
      activation and expansion of lymphocytes to generate protective or tolerogenic 
      immune responses.
FAU - Gabriele, Lucia
AU  - Gabriele L
AD  - Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale 
      Regina Elena 299, 00161 Roma, Italy. lucia.gabriele@iss.it
FAU - Ozato, Keiko
AU  - Ozato K
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070816
PL  - England
TA  - Cytokine Growth Factor Rev
JT  - Cytokine & growth factor reviews
JID - 9612306
RN  - 0 (Interferon Regulatory Factors)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Dendritic Cells/*cytology/immunology
MH  - Humans
MH  - Interferon Regulatory Factors/*immunology
RF  - 68
EDAT- 2007/08/19 09:00
MHDA- 2008/01/04 09:00
CRDT- 2007/08/19 09:00
PHST- 2007/08/19 09:00 [pubmed]
PHST- 2008/01/04 09:00 [medline]
PHST- 2007/08/19 09:00 [entrez]
AID - S1359-6101(07)00077-9 [pii]
AID - 10.1016/j.cytogfr.2007.06.008 [doi]
PST - ppublish
SO  - Cytokine Growth Factor Rev. 2007 Oct-Dec;18(5-6):503-10. doi: 
      10.1016/j.cytogfr.2007.06.008. Epub 2007 Aug 16.