PMID- 1770292
OWN - NLM
STAT- MEDLINE
DCOM- 19920227
LR  - 20210217
IS  - 0022-2275 (Print)
IS  - 0022-2275 (Linking)
VI  - 32
IP  - 11
DP  - 1991 Nov
TI  - Hyperlipoproteinemia in Nagase analbuminemic rats: effects of pravastatin on 
      plasma (apo)lipoproteins and lecithin:cholesterol acyltransferase activity.
PG  - 1719-28
AB  - The present study demonstrates very high levels of plasma lipids and high density 
      lipoprotein (HDL) apolipoproteins (apoA-I and apoE) in female Nagase 
      analbuminemic rats (NAR) fed a semi-synthetic diet in order to further increase 
      the hyperlipidemia present in this strain. Plasma apoB-containing lipoproteins 
      (very low, intermediate, and low density lipoproteins) were also elevated in NAR. 
      Plasma cholesterol was mainly present in lipoprotein particles with a density 
      between 1.02 and 1.12 g/ml. Separation of lipoprotein classes by gel filtration 
      showed that the major cholesterol-carrying lipoprotein fractions in NAR plasma 
      are apoE-rich HDL and apoA-I-rich HDL. The high HDL levels in NAR are explained, 
      at least partly, by the two- to threefold elevated activity of plasma 
      lecithin:cholesterol acyltransferase (LCAT). The lysophosphatidylcholine 
      generated in the LCAT reaction, as well as plasma free fatty acids, are bound to 
      lipoproteins in NAR plasma. A study was carried out to determine whether the 
      elevated LDL and aopoE-rich HDL levels could be corrected by administration of 
      the HMG-CoA reductase inhibitor pravastatin (at a dose of 1 mg/kg per day). 
      Pravastatin treatment results in a 43% decrease in plasma triglycerides in NAR, 
      but not in Sprague-Dawley (SDR) rats, and had no significant effect on plasma 
      total cholesterol, phospholipids apolipoproteins A-I, A-IV, B, or E, as well as 
      on plasma LCAT activity levels in NAR or SDR.
FAU - Van Tol, A
AU  - Van Tol A
AD  - Department of Biochemistry, Erasmus University, Rotterdam, The Netherlands.
FAU - Jansen, E H
AU  - Jansen EH
FAU - Koomans, H A
AU  - Koomans HA
FAU - Joles, J A
AU  - Joles JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Lipid Res
JT  - Journal of lipid research
JID - 0376606
RN  - 0 (Apolipoproteins)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Phospholipids)
RN  - EC 2.3.1.43 (Phosphatidylcholine-Sterol O-Acyltransferase)
RN  - KXO2KT9N0G (Pravastatin)
SB  - IM
MH  - Animals
MH  - Apolipoproteins/*blood
MH  - Chromatography, Gel
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Hyperlipoproteinemias/*blood
MH  - Phosphatidylcholine-Sterol O-Acyltransferase/*metabolism
MH  - Phospholipids/blood
MH  - Pravastatin/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1991/11/01 00:00
MHDA- 1991/11/01 00:01
CRDT- 1991/11/01 00:00
PHST- 1991/11/01 00:00 [pubmed]
PHST- 1991/11/01 00:01 [medline]
PHST- 1991/11/01 00:00 [entrez]
AID - S0022-2275(20)41627-X [pii]
PST - ppublish
SO  - J Lipid Res. 1991 Nov;32(11):1719-28.