PMID- 17704922
OWN - NLM
STAT- MEDLINE
DCOM- 20080306
LR  - 20181113
IS  - 0179-0358 (Print)
IS  - 0179-0358 (Linking)
VI  - 23
IP  - 11
DP  - 2007 Nov
TI  - The protective effects of trimetazidine on testicular ischemia and reperfusion 
      injury in rats.
PG  - 1113-8
AB  - This study was designed to investigate the protective effect of trimetazidine 
      [TMZ; 1-(2, 3, 4-trimethhoxibenzyl)-piperazine dihydrochloride], as an 
      antioxidant agent, on torsion-detorsion-induced biochemical and histopathological 
      changes in experimental testicular ischemia/reperfusion injury in rats. 
      Twenty-seven male Wistar rats weighing 180-220 g were divided into five groups: 
      control (C, n = 4), sham-operated (S, n = 4), ischemia (I, n = 6), 
      ischemia-reperfusion (I/R, n = 6) and ischemia-reperfusion + trimetazidine (I/R + 
      TMZ; n = 7). Control rats were used for basal normal values. In group I, 2 h 
      torsion of the left testis was performed. In I/R and I/R + TMZ groups, following 
      2 h of torsion, 4 h detorsion of the testis was performed. In ischemia and I/R 
      groups, physiologic saline was administered orally for 7 days, and the rats in 
      I/R + TMZ group were pretreated orally with 5 mg/kg day TMZ for 7 days before 
      inducing ischemia. At the end of each experiment, ipsilateral orchiectomies were 
      performed for the tissue levels of malondialdehyde (MDA), glutathione peroxidase 
      (GPx) enzyme activities and histopathological examinations in all groups. MDA 
      levels were significantly reduced and GPx enzyme activities were significantly 
      increased in testes in I/R+TMZ pretreated group compared to group I and I/R. The 
      mean seminiferous tubular diameter (MSTD) and Johnsen's score were significantly 
      better in I/R+TMZ group than groups I and I/R. Pretreatment with TMZ decreased 
      germ cell apoptosis and caspase-3 expression in the ischemic testis. The present 
      results show that TMZ has a protective activity in the testicular injury caused 
      by I/R, and provide the first evidence of the role of TMZ for the prevention of 
      I/R-induced testicular injury.
FAU - Pekcetin, Cetin
AU  - Pekcetin C
AD  - Department of Histology and Embryology, Dokuz Eylul University Medical School, 
      Balcova, Izmi 35340, Turkey.
FAU - Ergur, Bekir Ugur
AU  - Ergur BU
FAU - Kiray, Muge
AU  - Kiray M
FAU - Bagriyanik, Alper
AU  - Bagriyanik A
FAU - Tugyan, Kazim
AU  - Tugyan K
FAU - Erbil, Guven
AU  - Erbil G
FAU - Ozogul, Candan
AU  - Ozogul C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20070818
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
RN  - 0 (Vasodilator Agents)
RN  - EC 3.4.22.- (Caspase 3)
RN  - N9A0A0R9S8 (Trimetazidine)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Caspase 3/biosynthesis
MH  - Disease Models, Animal
MH  - Follow-Up Studies
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Ischemia/metabolism/pathology/*prevention & control
MH  - Male
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/metabolism/pathology/*prevention & control
MH  - Spermatic Cord Torsion/complications
MH  - Spermatozoa/drug effects/pathology
MH  - Testis/*blood supply
MH  - Treatment Outcome
MH  - Trimetazidine/*therapeutic use
MH  - Vasodilator Agents/*therapeutic use
EDAT- 2007/08/21 09:00
MHDA- 2008/03/07 09:00
CRDT- 2007/08/21 09:00
PHST- 2007/07/30 00:00 [accepted]
PHST- 2007/08/21 09:00 [pubmed]
PHST- 2008/03/07 09:00 [medline]
PHST- 2007/08/21 09:00 [entrez]
AID - 10.1007/s00383-007-2002-y [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2007 Nov;23(11):1113-8. doi: 10.1007/s00383-007-2002-y. Epub 
      2007 Aug 18.