PMID- 17706801
OWN - NLM
STAT- MEDLINE
DCOM- 20080228
LR  - 20131121
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 144
IP  - 1-3
DP  - 2007 Dec 4
TI  - CART peptide 55-102 microinjected into the nucleus accumbens inhibits the 
      expression of behavioral sensitization by amphetamine.
PG  - 6-9
AB  - CART peptide has been shown to regulate the actions of psychomotor stimulants. 
      Here we have further investigated the role of the biologically active CART 55-102 
      peptide in the nucleus accumbens (NAcc) in the expression of behavioral 
      sensitization by amphetamine (AMPH). Rats were pre-exposed 5 times to either 
      saline or AMPH (1 mg/kg, i.p.). After 2 weeks of withdrawal, rats were 
      microinjected into the NAcc with saline or CART 55-102 (1.0, or 2.5 microg/0.5 
      microl/side) followed by AMPH challenge (1 mg/kg, i.p.). The enhanced increase of 
      locomotion and rearing produced by repeated AMPH pre-exposures was 
      dose-dependently inhibited by microinjection into the NAcc of CART 55-102 
      peptide. These results indicate that CART 55-102 peptide in the NAcc can play a 
      compensatory inhibitory role in the expression of behavioral sensitization by 
      AMPH and further suggest that CART peptide may be a useful target to control the 
      drug addiction by psychomotor stimulants.
FAU - Kim, Seungwoo
AU  - Kim S
AD  - Department of Physiology, Brain Korea 21 Project for Medical Science, Brain 
      Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
FAU - Yoon, Hyung Shin
AU  - Yoon HS
FAU - Kim, Jeong-Hoon
AU  - Kim JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070717
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (cocaine- and amphetamine-regulated transcript protein (55-102))
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*antagonists & inhibitors
MH  - Animals
MH  - Behavior, Animal/*drug effects/physiology
MH  - Central Nervous System Stimulants/*antagonists & inhibitors
MH  - Locomotion/drug effects/radiation effects
MH  - Male
MH  - Microinjections
MH  - Nerve Tissue Proteins/administration & dosage/*pharmacology
MH  - Nucleus Accumbens/*drug effects/physiology
MH  - Peptide Fragments/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2007/08/21 09:00
MHDA- 2008/02/29 09:00
CRDT- 2007/08/21 09:00
PHST- 2007/03/13 00:00 [received]
PHST- 2007/06/08 00:00 [revised]
PHST- 2007/07/06 00:00 [accepted]
PHST- 2007/08/21 09:00 [pubmed]
PHST- 2008/02/29 09:00 [medline]
PHST- 2007/08/21 09:00 [entrez]
AID - S0167-0115(07)00129-2 [pii]
AID - 10.1016/j.regpep.2007.07.003 [doi]
PST - ppublish
SO  - Regul Pept. 2007 Dec 4;144(1-3):6-9. doi: 10.1016/j.regpep.2007.07.003. Epub 2007 
      Jul 17.