PMID- 17706869
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20080414
IS  - 1872-6623 (Electronic)
IS  - 0304-3959 (Linking)
VI  - 136
IP  - 1-2
DP  - 2008 May
TI  - The role of neurotrophic factors in genesis and maintenance of mechanical 
      hypernociception after brachial plexus avulsion in mice.
PG  - 125-33
AB  - Neurotrophic factors (NTFs), namely nerve growth factor (NGF), glial cell 
      line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) 
      and neurotrophin-3 (NT-3), have recently emerged as a new exciting class of 
      potential targets for the development of drugs to treat chronic pain. We have 
      recently reported that brachial plexus avulsion (BPA) results in a marked and 
      long-lasting mechanical hypernociception in rodents. Here we demonstrate that 
      antibodies against NGF, NT-3, GDNF and BDNF were able to postpone the mechanical 
      hypernociception in mice when dosed locally, systemically or intrathecally (i.t.) 
      at the time of surgery. However, none of them were able to interfere with the 
      mechanical hypernociception when administered intraventricularly (i.c.v.) at the 
      moment of surgery or even i.p. on the 4th day after the injury. Interestingly, 
      the anti-BDNF antibody was the only one that substantially reversed the 
      mechanical hypernociceptive state when administered i.t. or i.c.v. on the 4th day 
      after the BPA. We might suggest that NTFs, notably BDNF, are involved in the 
      mechanisms underlying neuropathic pain-like behavior following BPA. These pieces 
      of evidence corroborate the notion that NTF blockers might represent a new and 
      interesting option for the management of neuropathic pain.
FAU - Quintao, Nara Lins Meira
AU  - Quintao NL
AD  - Department of Pharmacology, Centre of Biological Sciences, Universidade Federal 
      de Santa Catarina, 88049-900 Florianopolis, SC, Brazil.
FAU - Santos, Adair Roberto Soares
AU  - Santos AR
FAU - Campos, Maria Martha
AU  - Campos MM
FAU - Calixto, Joao B
AU  - Calixto JB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070815
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (Antibodies)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Brachial Plexus/*injuries/*physiology/surgery
MH  - Female
MH  - Hyperalgesia/*etiology/*physiopathology
MH  - Mice
MH  - Nerve Growth Factors/antagonists & inhibitors/*physiology
MH  - Pain Measurement/methods
MH  - Physical Stimulation/methods
EDAT- 2007/08/21 09:00
MHDA- 2008/07/30 09:00
CRDT- 2007/08/21 09:00
PHST- 2006/04/25 00:00 [received]
PHST- 2007/06/14 00:00 [revised]
PHST- 2007/06/20 00:00 [accepted]
PHST- 2007/08/21 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2007/08/21 09:00 [entrez]
AID - S0304-3959(07)00351-X [pii]
AID - 10.1016/j.pain.2007.06.027 [doi]
PST - ppublish
SO  - Pain. 2008 May;136(1-2):125-33. doi: 10.1016/j.pain.2007.06.027. Epub 2007 Aug 
      15.