PMID- 17709321
OWN - NLM
STAT- MEDLINE
DCOM- 20071010
LR  - 20171116
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 128
IP  - 3
DP  - 2007 Sep
TI  - MALT lymphoma involving the kidney: a report of 10 cases and review of the 
      literature.
PG  - 464-73
AB  - Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue 
      (MALT lymphoma) can arise at any anatomic site, but involvement of the kidney is 
      rare. We describe 10 cases of kidney MALT lymphoma, including 6 localized cases. 
      No predisposing inflammatory conditions were identified, with the possible 
      exception of coexistent renal Actinomyces infection in 1 case. We performed 
      fluorescence in situ hybridization (FISH) using a malt1 break-apart probe in 7 
      cases. A malt1 gene rearrangement was identified in 1 case (14%). This case was 
      further assessed by FISH using an IgH breakapart probe that showed IgH gene 
      rearrangement. These results are suggestive of the t(14;18) involving malt1 and 
      IgH. Immunostaining for NF-kappaB p65 showed nuclear positivity, consistent with 
      NF-kappaB activation, in 3 of 5 cases assessed. Our results indicate that kidney 
      MALT lymphomas share similarities with MALT lymphomas arising at other sites in 
      that MALT lymphoma-associated translocations and NF-kappaB activation occur in a 
      subset of cases.
FAU - Garcia, Mar
AU  - Garcia M
AD  - The Department of Hematopathology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX 77030, USA.
FAU - Konoplev, Sergej
AU  - Konoplev S
FAU - Morosan, Cristian
AU  - Morosan C
FAU - Abruzzo, Lynne V
AU  - Abruzzo LV
FAU - Bueso-Ramos, Carlos E
AU  - Bueso-Ramos CE
FAU - Medeiros, L Jeffrey
AU  - Medeiros LJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (NF-kappa B)
RN  - 0 (Neoplasm Proteins)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Caspases/*metabolism
MH  - Enzyme Activation
MH  - Female
MH  - Gene Rearrangement
MH  - Genes, Immunoglobulin Heavy Chain
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics/*metabolism/pathology
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - NF-kappa B/biosynthesis
MH  - Neoplasm Proteins/*metabolism
MH  - Translocation, Genetic
RF  - 34
EDAT- 2007/08/22 09:00
MHDA- 2007/10/11 09:00
CRDT- 2007/08/22 09:00
PHST- 2007/08/22 09:00 [pubmed]
PHST- 2007/10/11 09:00 [medline]
PHST- 2007/08/22 09:00 [entrez]
AID - 04L8G47618R4NXN8 [pii]
AID - 10.1309/0T2UKUKV91W3QR6W [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2007 Sep;128(3):464-73. doi: 10.1309/0T2UKUKV91W3QR6W.