PMID- 17709339
OWN - NLM
STAT- MEDLINE
DCOM- 20071018
LR  - 20130520
IS  - 1367-4811 (Electronic)
IS  - 1367-4803 (Linking)
VI  - 23
IP  - 18
DP  - 2007 Sep 15
TI  - A Laboratory Information Management System (LIMS) for a high throughput genetic 
      platform aimed at candidate gene mutation screening.
PG  - 2504-6
AB  - High throughput mutation screening in an automated environment generates large 
      data sets that have to be organized and stored reliably. Complex multistep 
      workflows require strict process management and careful data tracking. We have 
      developed a Laboratory Information Management Systems (LIMS) tailored to high 
      throughput candidate gene mutation scanning and resequencing that respects these 
      requirements. Designed with a client/server architecture, our system is platform 
      independent and based on open-source tools from the database to the web 
      application development strategy. Flexible, expandable and secure, the LIMS, by 
      communicating with most of the laboratory instruments and robots, tracks samples 
      and laboratory information, capturing data at every step of our automated 
      mutation screening workflow. An important feature of our LIMS is that it enables 
      tracking of information through a laboratory workflow where the process at one 
      step is contingent on results from a previous step. AVAILABILITY: Script for 
      MySQL database table creation and source code of the whole JSP application are 
      freely available on our website: http://www-gcs.iarc.fr/lims/. SUPPLEMENTARY 
      INFORMATION: System server configuration, database structure and additional 
      details on the LIMS and the mutation screening workflow are available on our 
      website: http://www-gcs.iarc.fr/lims/
FAU - Voegele, C
AU  - Voegele C
AD  - International Agency for Research on Cancer, Lyon, France. voegele@iarc.fr
FAU - Tavtigian, S V
AU  - Tavtigian SV
FAU - de Silva, D
AU  - de Silva D
FAU - Cuber, S
AU  - Cuber S
FAU - Thomas, A
AU  - Thomas A
FAU - Le Calvez-Kelm, F
AU  - Le Calvez-Kelm F
LA  - eng
PT  - Journal Article
DEP - 20070820
PL  - England
TA  - Bioinformatics
JT  - Bioinformatics (Oxford, England)
JID - 9808944
SB  - IM
MH  - Clinical Laboratory Techniques
MH  - *Computer Communication Networks
MH  - DNA Mutational Analysis/*methods
MH  - *Database Management Systems
MH  - *Databases, Genetic
MH  - Genetic Testing/*methods
MH  - Information Storage and Retrieval/*methods
MH  - *Software
MH  - Systems Integration
MH  - User-Computer Interface
EDAT- 2007/08/22 09:00
MHDA- 2007/10/19 09:00
CRDT- 2007/08/22 09:00
PHST- 2007/08/22 09:00 [pubmed]
PHST- 2007/10/19 09:00 [medline]
PHST- 2007/08/22 09:00 [entrez]
AID - btm365 [pii]
AID - 10.1093/bioinformatics/btm365 [doi]
PST - ppublish
SO  - Bioinformatics. 2007 Sep 15;23(18):2504-6. doi: 10.1093/bioinformatics/btm365. 
      Epub 2007 Aug 20.