PMID- 17711202
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20190715
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 41
IP  - 14
DP  - 2007 Jul 15
TI  - Dietary exposure of juvenile rainbow trout (Oncorhynchus mykiss) to 
      1,2-bis(2,4,6-tribromophenoxy)ethane: bioaccumulation parameters, biochemical 
      effects, and metabolism.
PG  - 4913-8
AB  - Juvenile rainbow trout (Oncorhynchus mykiss) were exposed in the laboratory to an 
      environmentally relevant dose of 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) via 
      their diet for 49 days, followed by 154 days of untreated food to examine 
      bioaccumulation parameters, potential biochemical effects, and metabolic 
      products. There was a linear increase in the amount of BTBPE in fish during the 
      uptake phase of the experiment, and an uptake rate constant of 0.0069 +/- 0.0012 
      (arithmetic mean +/- 1 x standard error) nmoles per day was calculated. The 
      elimination of BTBPE from the fish obeyed first-order depuration kinetics (r2 = 
      0.6427, p < 0.001) with a calculated half-life of 54.1 +/- 8.5 days. The derived 
      biomagnification factor of 2.3 +/- 0.9 suggests that this chemical has a high 
      potential for biomagnification in aquatic food webs. Debrominated and 
      hydroxylated metabolites were not detected in liver extracts and suggest that 
      either biotransformation or storage of BTBPE-metabolites in the hepatic system of 
      fish is minor or that our exposure time frame was too short. Similar 
      concentrations of circulating thyroid hormones, liver deiodinase enzyme activity, 
      and thyroid glandular histology suggest that BTBPE is not a potent thyroid axis 
      disruptor.
FAU - Tomy, Gregg T
AU  - Tomy GT
AD  - Department of Fisheries and Oceans, Freshwater Institute, Winnipeg, Manitoba R3T 
      2N6, Canada. tomyg@dfo-mpo.gc.ca
FAU - Palace, Vince P
AU  - Palace VP
FAU - Pleskach, Kerri
AU  - Pleskach K
FAU - Ismail, Nargis
AU  - Ismail N
FAU - Oswald, Tyler
AU  - Oswald T
FAU - Danell, Robert
AU  - Danell R
FAU - Wautier, Kerry
AU  - Wautier K
FAU - Evans, Bob
AU  - Evans B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Bromobenzenes)
RN  - 0 (Water Pollutants, Chemical)
RN  - 34I00D6RNM (1,2-bis(2,4,6-tribromophenoxy)ethane)
SB  - IM
MH  - Animals
MH  - Bromobenzenes/*pharmacokinetics
MH  - *Diet
MH  - Oncorhynchus mykiss/growth & development/metabolism
MH  - Reference Standards
MH  - Water Pollutants, Chemical/*pharmacokinetics
EDAT- 2007/08/23 09:00
MHDA- 2007/10/13 09:00
CRDT- 2007/08/23 09:00
PHST- 2007/08/23 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2007/08/23 09:00 [entrez]
AID - 10.1021/es070288t [doi]
PST - ppublish
SO  - Environ Sci Technol. 2007 Jul 15;41(14):4913-8. doi: 10.1021/es070288t.