PMID- 17711313
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20070918
IS  - 0743-7463 (Print)
IS  - 0743-7463 (Linking)
VI  - 23
IP  - 20
DP  - 2007 Sep 25
TI  - Adsorption kinetics of carcinogens to DNA liquid crystalline gel beads.
PG  - 10081-7
AB  - Adsorption behaviors of acridine orange (AO) and biphenyl (BP) to DNA liquid 
      crystalline gel (LCG) beads in aqueous dispersing solution have been studied 
      theoretically and experimentally. A theoretical consideration based on 
      nonequilibrium thermodynamics predicted that the time course of the adsorption 
      process is expressed with a scaled equation, and a scaled number of adsorbed 
      carcinogen molecules n is expressed with the square root of a scaled immersion 
      time t, n proportional, variant square root t at early stage, whereas it is 
      expressed with a power law function 1 - n proportional, variant (te - t)3/2 for 
      n0 > 1 and an exponential equation n0 - n proportional, variant e-t/alpha tau0 
      for n0 > 1 at later stages of adsorption. Here, n0 is the ratio of the initial 
      number of carcinogen molecules in the dispersing solution to the number of the 
      sites of adsorption of carcinogen molecules in the beads, te is the scaled 
      equilibrium time of adsorption, tau0 is a time constant for adsorption, and alpha 
      is a constant. Observed adsorption processes for AO were well expressed by the 
      predicted ones, and the fitting parameters n0 and tau0 increased with increasing 
      cobalt chloride concentration CCo used for preparation of the beads, and both 
      saturated above CCo > or = 400 mM for the adsorption of AO, whereas the 
      adsorption processes for BP were expressed with the square root function. These 
      results indicate that (1) the adsorption process at early stage is explained by 
      diffusion-limited binding of the carcinogen molecules to DNA beads, and the time 
      range of the early stage depends on the solubility (the solubility of AO in water 
      is high whereas that of BP is low); and (2) the process at later stages depends 
      on the balance of the numbers of adsorption sites and carcinogen molecules.
FAU - Furusawa, Kazuya
AU  - Furusawa K
AD  - Department of Chemistry and Chemical Biology, Gunma University, Kiryu, Gunma 
      376-8515, Japan.
FAU - Wakamatsu, Masako
AU  - Wakamatsu M
FAU - Dobashi, Toshiaki
AU  - Dobashi T
FAU - Yamamoto, Takao
AU  - Yamamoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070821
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Carcinogens)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adsorption
MH  - Carcinogens/*chemistry
MH  - Crystallization
MH  - DNA/*chemistry
MH  - Kinetics
EDAT- 2007/08/23 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/08/23 09:00
PHST- 2007/08/23 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/08/23 09:00 [entrez]
AID - 10.1021/la701379q [doi]
PST - ppublish
SO  - Langmuir. 2007 Sep 25;23(20):10081-7. doi: 10.1021/la701379q. Epub 2007 Aug 21.