PMID- 17711377
OWN - NLM
STAT- MEDLINE
DCOM- 20071023
LR  - 20070822
IS  - 1087-2914 (Print)
IS  - 1087-2914 (Linking)
VI  - 21
IP  - 8
DP  - 2007 Aug
TI  - Immune reconstitution inflammatory syndrome associated with disseminated 
      mycobacterial infection in patients with AIDS.
PG  - 527-32
AB  - Restoration of the immune system after highly active antiretroviral therapy 
      (HAART) resulting from a quantitative and qualitative process of cell immune 
      activity recovery may evolve with adverse clinical phenomena, known as the immune 
      reconstitution inflammatory syndrome (IRIS). It can occur in association with 
      several opportunist infections, although most reported cases have been related to 
      mycobacterial infection caused by Mycobacterium tuberculosis and Mycobacterium 
      avium. We describe three clinical cases of mycobacterial infection with different 
      presentation patterns of IRIS after HAART. In each of these patients, immune 
      reconstitution led to clinical manifestation of a latent infection, or clinical 
      worsening of preexisting lesions, or manifestation of new lesions in the central 
      nervous system. Clinical aspects of IRIS are presented in the paper and clinical 
      management options for this event are carefully discussed.
FAU - Tuon, Felipe Francisco
AU  - Tuon FF
AD  - Department of Infectious and Parasitic Diseases, School of Medicine, University 
      of Sao Paulo, SP, Brazil. ffbt@pop.com.br
FAU - Mulatti, Grace Carvajal
AU  - Mulatti GC
FAU - Pinto, Walkyria Pereira
AU  - Pinto WP
FAU - de Siqueira Franca, Francisco Oscar
AU  - de Siqueira Franca FO
FAU - Gryschek, Ronaldo Cesar
AU  - Gryschek RC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - AIDS Patient Care STDS
JT  - AIDS patient care and STDs
JID - 9607225
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active
MH  - HIV Infections/drug therapy/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium Infections/*complications
MH  - Mycobacterium avium Complex/isolation & purification
MH  - Mycobacterium avium-intracellulare Infection/complications/diagnosis/microbiology
MH  - Mycobacterium tuberculosis/isolation & purification
MH  - Systemic Inflammatory Response Syndrome/*complications
MH  - Tuberculosis, Central Nervous System/complications/diagnosis/microbiology
MH  - Tuberculosis, Pulmonary/complications/diagnosis/microbiology
EDAT- 2007/08/23 09:00
MHDA- 2007/10/24 09:00
CRDT- 2007/08/23 09:00
PHST- 2007/08/23 09:00 [pubmed]
PHST- 2007/10/24 09:00 [medline]
PHST- 2007/08/23 09:00 [entrez]
AID - 10.1089/apc.2006.0121 [doi]
PST - ppublish
SO  - AIDS Patient Care STDS. 2007 Aug;21(8):527-32. doi: 10.1089/apc.2006.0121.