PMID- 17712353
OWN - NLM
STAT- MEDLINE
DCOM- 20080807
LR  - 20220129
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 33
IP  - 6
DP  - 2008 May
TI  - Differential effects of nucleus accumbens core, shell, or dorsal striatal 
      inactivations on the persistence, reacquisition, or reinstatement of responding 
      for a drug-paired conditioned reinforcer.
PG  - 1413-25
AB  - Drug-paired conditioned reinforcers can maintain persistent instrumental 
      responding, thus providing a model of some aspects of long-term drug addiction. 
      The purpose of the present study was to investigate the effects of inactivating 
      the dorsal striatum (DStr), nucleus accumbens (NAcc) core, or NAcc shell on 
      different types of responding, each maintained by drug-paired conditioned 
      reinforcers. Inactivations were achieved by infusing a combination of baclofen 
      and muscimol prior to (1) persistent responding for a drug-paired conditioned 
      reinforcer, (2) reacquisition of this instrumental response after extinction by 
      omission of the contingent conditioned stimulus (CS), or (3) CS (cue)-induced 
      reinstatement of the original (and different) instrumental response that had 
      previously delivered cocaine. Inactivation of the DStr attenuated persistent 
      responding for a cocaine-paired conditioned reinforcer, as well as its 
      reacquisition after extinction of this response, while the only effect of 
      inactivation of the NAcc shell was to increase CS (cue)-induced reinstatement of 
      the extinguished instrumental response that had previously delivered cocaine. 
      Inactivation of the NAcc core affected all measures of responding maintained by 
      drug-paired conditioned reinforcers. These results are discussed with reference 
      to the neural systems involved in different aspects of responding maintained by 
      drug-paired conditioned reinforcers.
FAU - Di Ciano, Patricia
AU  - Di Ciano P
AD  - Department of Experimental Psychology, University of Cambridge, Cambridge, UK. 
      p.diciano@swansea.ac.uk
FAU - Robbins, Trevor W
AU  - Robbins TW
FAU - Everitt, Barry J
AU  - Everitt BJ
LA  - eng
GR  - G0001354/MRC_/Medical Research Council/United Kingdom
GR  - G0600196/MRC_/Medical Research Council/United Kingdom
GR  - g9536855/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070822
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Cocaine/*administration & dosage
MH  - Cocaine-Related Disorders/*psychology
MH  - Conditioning, Operant/*drug effects/physiology
MH  - Corpus Striatum/*drug effects/physiology
MH  - Cues
MH  - Dopamine Uptake Inhibitors/*administration & dosage
MH  - Exploratory Behavior/drug effects/physiology
MH  - Extinction, Psychological/drug effects
MH  - Male
MH  - Nucleus Accumbens/anatomy & histology/*drug effects/physiology
MH  - Rats
MH  - Reinforcement Schedule
MH  - Reinforcement, Psychology
EDAT- 2007/08/23 09:00
MHDA- 2008/08/08 09:00
CRDT- 2007/08/23 09:00
PHST- 2007/08/23 09:00 [pubmed]
PHST- 2008/08/08 09:00 [medline]
PHST- 2007/08/23 09:00 [entrez]
AID - 1301522 [pii]
AID - 10.1038/sj.npp.1301522 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2008 May;33(6):1413-25. doi: 10.1038/sj.npp.1301522. 
      Epub 2007 Aug 22.