PMID- 17712472
OWN - NLM
STAT- MEDLINE
DCOM- 20080102
LR  - 20131121
IS  - 1684-1182 (Print)
IS  - 1684-1182 (Linking)
VI  - 40
IP  - 4
DP  - 2007 Aug
TI  - Immune response to ovalbumin following bisphenol A administration in mice fed 
      with a low level of dietary protein.
PG  - 364-70
AB  - BACKGROUND AND PURPOSE: We have previously shown that bisphenol A (BPA) augments 
      T-helper (Th) 1 activity with no significant effects on an established oral 
      tolerance to ovalbumin (OVA) in mice fed with a normal protein diet. The present 
      study aimed to examine the effect of BPA on the immune response in a mouse model 
      maintained on a very low protein diet (5% casein). METHODS: Mice were fed on a 5% 
      protein diet, together with either OVA (OVA-fed) or water (water-fed), immunized 
      intraperitoneally with OVA at 3-week intervals and administered BPA between the 2 
      immunizations. A week after the last immunization, animals were sacrificed and 
      examined by enzyme-linked immunosorbent assay for serum titers of total 
      immunoglobulin E (IgE), OVA-specific IgE, immunoglobulin G (IgG), IgG1, IgG2a, 
      and the production of interferon-gamma, interleukin (IL)-4, and IL-12. RESULTS: 
      In both BPA-treated and non-treated animals, OVA feeding resulted in lower titers 
      of total and OVA-specific IgE, and OVA-specific IgG (p<0.05). There were higher 
      levels of interferon-gamma (p<0.05), IL-4, and IL-12 (p<0.05) in animals with OVA 
      tolerance following BPA treatment. However, IL-12 production was augmented only 
      in BPA-treated water-fed animals (p<0.01). CONCLUSION: BPA administration in mice 
      fed with a low level of dietary protein augmented Th1 cytokines more profoundly 
      in the animals with OVA tolerance than in the non-tolerant animals.
FAU - Alizadeh, Mohammad
AU  - Alizadeh M
AD  - Department of Preventive Environment and Nutrition, Institute of Health 
      Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
FAU - Ota, Fusao
AU  - Ota F
FAU - Kassu, Afework
AU  - Kassu A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Phenols)
RN  - 187348-17-0 (Interleukin-12)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds
MH  - Cells, Cultured
MH  - *Diet, Protein-Restricted
MH  - Immune System
MH  - Immune Tolerance
MH  - Immunization
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/*immunology
MH  - Interferon-gamma/biosynthesis/immunology
MH  - Interleukin-12/biosynthesis/immunology
MH  - Interleukin-4/biosynthesis/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/administration & dosage/*immunology
MH  - Phenols/administration & dosage/*immunology
MH  - Spleen
MH  - Th1 Cells/immunology/metabolism
EDAT- 2007/08/23 09:00
MHDA- 2008/01/03 09:00
CRDT- 2007/08/23 09:00
PHST- 2007/08/23 09:00 [pubmed]
PHST- 2008/01/03 09:00 [medline]
PHST- 2007/08/23 09:00 [entrez]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2007 Aug;40(4):364-70.