PMID- 17714418
OWN - NLM
STAT- MEDLINE
DCOM- 20080606
LR  - 20211203
IS  - 0041-1132 (Print)
IS  - 0041-1132 (Linking)
VI  - 47
IP  - 12
DP  - 2007 Dec
TI  - The alloimmune response to the human platelet antigen-1a is not related to 
      maternal-fetal killer immunoglobulinlike receptor/HLA-Cw combinations.
PG  - 2322-9
AB  - BACKGROUND: Human platelet antigen (HPA)-1a fetomaternal alloimmune 
      thrombocytopenia, responsible in the most severe cases for fetal or neonatal 
      intracranial hemorrhages leading to death or survival with neurologic sequelae, 
      was shown to be restricted to the human leukocyte antigen (HLA) Class II 
      DRB3*0101-encoded molecule. Whereas more than 90 percent of alloimmunized mothers 
      display the DRB3*0101 allele, the positive predictive value of the presence of 
      DRB3*0101 is only 35 percent. Additional genetic risk factors may exist of which 
      elucidation could improve the undertaking of incompatible pregnancies in at-risk 
      families, encouraging an antenatal screening. Interactions of killer 
      immunoglobulinlike receptors (KIRs) on maternal decidual NK cells with HLA-Cw 
      molecules on fetal trophoblasts were reported as one of the mechanisms involved 
      in the fetomaternal tolerance during pregnancy. STUDY DESIGN AND METHODS: 
      Genotyping was performed of 16 KIR genes in HPA-1a-negative/DRB3*0101-positive 
      alloimmunized mothers and in HPA-1a-negative/DRB3*0101-positive nonimmunized 
      mothers as well as HLA-Cw genotyping in thrombocytopenic children and their 
      nonaffected siblings. RESULTS: No particular KIR genes or KIR genotypes were 
      observed in the alloimmunized or nonimmunized mothers. Distribution of HLA-Cw 
      genes in affected infants and nonaffected siblings did not reveal any HLA-Cw 
      specificity associated with triggering or modulation of the HPA-1a 
      alloimmunization. No maternal KIR/fetal HLA-Cw combinations were demonstrated in 
      association with a detrimental or a protective effect on the HPA-1a 
      alloimmunization. CONCLUSION: Maternal KIR/fetal HLA-Cw gene combinations that 
      are involved in the fetomaternal tolerance do not appear to play a role in the 
      HPA-1a alloimmunization.
FAU - Valentin, Nathalie
AU  - Valentin N
AD  - Laboratoire d'Immunologie, Institut de Biologie, CHU Nantes, France. 
      nathalie.valentin@chu-nantes.fr
FAU - Gagne, Katia
AU  - Gagne K
FAU - Kerdudou, Nolwenn
AU  - Kerdudou N
FAU - Halle, Liliane
AU  - Halle L
FAU - Kaplan, Cecile
AU  - Kaplan C
FAU - Killie, Mette Kjaer
AU  - Killie MK
FAU - Skogen, Bjorn
AU  - Skogen B
FAU - Muller, Jean-Yves
AU  - Muller JY
FAU - Bignon, Jean-Denis
AU  - Bignon JD
LA  - eng
PT  - Journal Article
DEP - 20070821
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Antigens, Human Platelet)
RN  - 0 (HLA Antigens)
RN  - 0 (ITGB3 protein, human)
RN  - 0 (Integrin beta3)
RN  - 0 (Isoantibodies)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Antigens, Human Platelet/*immunology
MH  - Female
MH  - Genotype
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Integrin beta3
MH  - Isoantibodies/immunology
MH  - Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Receptors, KIR/*genetics/immunology
EDAT- 2007/08/24 09:00
MHDA- 2008/06/07 09:00
CRDT- 2007/08/24 09:00
PHST- 2007/08/24 09:00 [pubmed]
PHST- 2008/06/07 09:00 [medline]
PHST- 2007/08/24 09:00 [entrez]
AID - TRF01450 [pii]
AID - 10.1111/j.1537-2995.2007.01450.x [doi]
PST - ppublish
SO  - Transfusion. 2007 Dec;47(12):2322-9. doi: 10.1111/j.1537-2995.2007.01450.x. Epub 
      2007 Aug 21.