PMID- 17714869
OWN - NLM
STAT- MEDLINE
DCOM- 20080104
LR  - 20070827
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 424
IP  - 2
DP  - 2007 Sep 7
TI  - Diffusion tensor imaging of white matter in the superior temporal gyrus and 
      temporal stem in autism.
PG  - 127-32
AB  - Recent MRI studies have indicated that regions of the temporal lobe including the 
      superior temporal gyrus (STG) and the temporal stem (TS) appear to be abnormal in 
      autism. In this study, diffusion tensor imaging (DTI) measurements of white 
      matter in the STG and the TS were compared in 43 autism and 34 control subjects. 
      DTI measures of mean diffusivity, fractional anisotropy, axial diffusivity, and 
      radial diffusivity were compared between groups. In all regions, fractional 
      anisotropy was significantly decreased and both mean diffusivity and radial 
      diffusivity were significantly increased in the autism group. These results 
      suggest that white matter microstructure in autism is abnormal in these temporal 
      lobe regions, which is consistent with theories of aberrant brain connectivity in 
      autism.
FAU - Lee, Jee Eun
AU  - Lee JE
AD  - Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, Madison, WI, 
      United States.
FAU - Bigler, Erin D
AU  - Bigler ED
FAU - Alexander, Andrew L
AU  - Alexander AL
FAU - Lazar, Mariana
AU  - Lazar M
FAU - DuBray, Molly B
AU  - DuBray MB
FAU - Chung, Moo K
AU  - Chung MK
FAU - Johnson, Michael
AU  - Johnson M
FAU - Morgan, Jubel
AU  - Morgan J
FAU - Miller, Judith N
AU  - Miller JN
FAU - McMahon, William M
AU  - McMahon WM
FAU - Lu, Jeffrey
AU  - Lu J
FAU - Jeong, Eun-Kee
AU  - Jeong EK
FAU - Lainhart, Janet E
AU  - Lainhart JE
LA  - eng
GR  - DA15879/DA/NIDA NIH HHS/United States
GR  - HD35476/HD/NICHD NIH HHS/United States
GR  - MH 62015/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070806
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anisotropy
MH  - Autistic Disorder/*pathology
MH  - Brain Mapping
MH  - Brain Stem/*pathology
MH  - Child
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Humans
MH  - Male
MH  - Organ Size
MH  - Temporal Lobe/*pathology
EDAT- 2007/08/24 09:00
MHDA- 2008/01/05 09:00
CRDT- 2007/08/24 09:00
PHST- 2007/04/23 00:00 [received]
PHST- 2007/07/02 00:00 [revised]
PHST- 2007/07/24 00:00 [accepted]
PHST- 2007/08/24 09:00 [pubmed]
PHST- 2008/01/05 09:00 [medline]
PHST- 2007/08/24 09:00 [entrez]
AID - S0304-3940(07)00823-3 [pii]
AID - 10.1016/j.neulet.2007.07.042 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Sep 7;424(2):127-32. doi: 10.1016/j.neulet.2007.07.042. Epub 
      2007 Aug 6.