PMID- 1771630
OWN - NLM
STAT- MEDLINE
DCOM- 19920221
LR  - 20190824
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 37
IP  - 5
DP  - 1991 May
TI  - Probabilistic assessment of the HLA sharing of recurrent spontaneous abortion 
      couples in the Japanese population.
PG  - 211-7
AB  - In spite of a number of investigations, the concept of human leukocyte antigen 
      (HLA) sharing in recurrent spontaneous abortion (RSA) couples remains 
      controversial. We introduced the basal antigen sharing rate (BSR) by the original 
      mathematical approach using the gene frequency of all HLA specificities derived 
      from our regional control population and applied this parameter for the 
      comparison with RSA couples. RSA couples were classified into three subgroups; 
      primary (3 or more consecutive abortions), secondary (3 or more consecutive 
      abortions after 1 live birth), and potential (2 consecutive abortions) aborters. 
      No significant differences between the HLA class I sharing rates (one or more 
      antigens shared on a single locus) of the all RSA subgroups and the calculated 
      BSRs were observed. In the HLA-DR and DQ loci, on the other hand, the antigen 
      sharing rates of primary aborters were significantly higher than BSRs (p less 
      than 0.01/DR, p less than 0.05/DQ). While potential aborters showed a result 
      similar to that of the primary aborters, no significant antigen sharing of HLA 
      class II was observed in secondary aborters. Our data suggest that BSR is a 
      useful parameter for detection of significant HLA sharing in regional populations 
      and the consecutive abortions that occurred primarily are certainly relevant to 
      HLA class II sharing.
FAU - Koyama, M
AU  - Koyama M
AD  - Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
FAU - Saji, F
AU  - Saji F
FAU - Takahashi, S
AU  - Takahashi S
FAU - Takemura, M
AU  - Takemura M
FAU - Samejima, Y
AU  - Samejima Y
FAU - Kameda, T
AU  - Kameda T
FAU - Kimura, T
AU  - Kimura T
FAU - Tanizawa, O
AU  - Tanizawa O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Abortion, Spontaneous/*epidemiology/genetics/immunology
MH  - Chromosome Mapping
MH  - DNA/genetics
MH  - Female
MH  - HLA Antigens/genetics/*immunology
MH  - HLA-DQ Antigens/genetics/immunology
MH  - HLA-DR Antigens/genetics/immunology
MH  - Histocompatibility Antigens Class I/genetics/immunology
MH  - Histocompatibility Antigens Class II/genetics/immunology
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Mathematics
MH  - Phenotype
MH  - Pregnancy
MH  - Probability
EDAT- 1991/05/01 00:00
MHDA- 1991/05/01 00:01
CRDT- 1991/05/01 00:00
PHST- 1991/05/01 00:00 [pubmed]
PHST- 1991/05/01 00:01 [medline]
PHST- 1991/05/01 00:00 [entrez]
AID - 10.1111/j.1399-0039.1991.tb01874.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1991 May;37(5):211-7. doi: 10.1111/j.1399-0039.1991.tb01874.x.