PMID- 17716911
OWN - NLM
STAT- MEDLINE
DCOM- 20080204
LR  - 20111117
IS  - 1044-579X (Print)
IS  - 1044-579X (Linking)
VI  - 17
IP  - 6
DP  - 2007 Dec
TI  - The role of HLA-G in gastrointestinal inflammatory disease and malignancy.
PG  - 451-8
AB  - Human leukocyte antigen (HLA)-G has been shown to act as an immune-inhibitory 
      molecule and to interfere with the normal functions of natural killer (NK) cells 
      and T-cells, conferring a potential route for HLA-G expressing cells to escape 
      host immune surveillance. These findings have led to the rather intense study of 
      HLA-G expression in several different arenas, including organ transplantation, 
      inflammatory conditions, and in a wide variety of neoplasms including 
      hematolymphoid neoplasms, visceral carcinomas, gliomas, and dermal-based 
      neoplasms. This review will focus on the role of HLA-G in inflammatory conditions 
      of the bowel, which can serve as an initiator of neoplastic alterations, as well 
      as examine HLA-G expression and function in a variety of gastrointestinal 
      malignancies. Although there are only a limited number of studies that have 
      examined HLA-G in the gastrointestinal tract, the role of HLA-G has been 
      controversial in this organ system with conflicting results reported even within 
      the same tumor type.
FAU - Downs-Kelly, Erinn
AU  - Downs-Kelly E
AD  - Department of Pathology and Laboratory Medicine, The Cleveland Clinic, L25, 9500 
      Euclid Ave., Cleveland, OH 44195, United States.
FAU - Schade, Andrew E
AU  - Schade AE
FAU - Hansel, Donna E
AU  - Hansel DE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070713
PL  - England
TA  - Semin Cancer Biol
JT  - Seminars in cancer biology
JID - 9010218
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Carcinoma/immunology/metabolism
MH  - Gastrointestinal Neoplasms/*immunology/metabolism
MH  - HLA Antigens/*immunology/metabolism
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*immunology/metabolism
MH  - Humans
MH  - Inflammatory Bowel Diseases/*immunology/metabolism
MH  - Tumor Escape
RF  - 72
EDAT- 2007/08/25 09:00
MHDA- 2008/02/05 09:00
CRDT- 2007/08/25 09:00
PHST- 2007/06/06 00:00 [received]
PHST- 2007/06/22 00:00 [revised]
PHST- 2007/07/04 00:00 [accepted]
PHST- 2007/08/25 09:00 [pubmed]
PHST- 2008/02/05 09:00 [medline]
PHST- 2007/08/25 09:00 [entrez]
AID - S1044-579X(07)00046-6 [pii]
AID - 10.1016/j.semcancer.2007.07.002 [doi]
PST - ppublish
SO  - Semin Cancer Biol. 2007 Dec;17(6):451-8. doi: 10.1016/j.semcancer.2007.07.002. 
      Epub 2007 Jul 13.