PMID- 17717670
OWN - NLM
STAT- MEDLINE
DCOM- 20081009
LR  - 20181113
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 28
IP  - 5
DP  - 2008 Mar
TI  - Frequency of HLA-B27 and its alleles in patients with Reiter syndrome: comparison 
      with the frequency in other spondyloarthropathies and a healthy control 
      population.
PG  - 483-6
AB  - This retrospective study analyzed the HLA-B 27 alleles in a group of 20 
      consecutive patients with the diagnosis of Reiter syndrome (RS) followed in a 
      tertiary referral university hospital in Brazil, during the period 1990-2006, and 
      compared the data with that observed in other patients with spondyloarthropathies 
      followed at the same institution. Eight cases were associated to gastrointestinal 
      infection, eight cases to previous urethritis, and four cases presented no 
      established preceding infection. HLA-B 27 alleles were typed by polymerase chain 
      reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes 
      (HLA-B 2,701 to HLA-B 2,721). They were compared to a group of 108 patients with 
      ankylosing spondylitis (AS), 40 with undifferentiated spondyloarthropathy (uSpA) 
      and 111 healthy controls. Among the 20 patients, 17 were HLA-B 27 positive (85%). 
      Two HLA-B 27 alleles were observed: HLA-B 2,705 (65%) and HLA-B 2,702 (35%). In 
      the other spondyloarthropathies, the observed alleles were HLA-B 2,705 (90% in AS 
      and 92.5% in uSpA), HLA-B 2,702 (8% in AS and 5% in uSpA), HLA-B 2,704 (1% in AS 
      and 2.5% in uSpA) and HLA-B 2,713 (1% in AS). Among the 111 healthy controls, 80% 
      presented HLA-B 2,705, followed by HLA-B 2,702 in 10%, HLA-B 2,703 in 6%, HLA-B 
      2,707 in 3% and HLA-B 2,713 in 1%. Concluding, in the HLA-B 27 positive patients 
      with RS in this study there was predominance of HLA-B 2,705 allele, in a lower 
      frequency than that observed in patients with other spondyloarthropathies and 
      healthy controls.
FAU - Sampaio-Barros, Percival D
AU  - Sampaio-Barros PD
AD  - Unit of Rheumatology, Department of Internal Medicine, State University of 
      Campinas Faculty of Medical Sciences (FCM/UNICAMP), Barao Geraldo, CEP: 
      13081-970, Campinas, SP, Brazil. psbarros@fcm.unicamp.br
FAU - Conde, Roseneide A
AU  - Conde RA
FAU - Donadi, Eduardo A
AU  - Donadi EA
FAU - Bonfiglioli, Rubens
AU  - Bonfiglioli R
FAU - Costallat, Lilian T L
AU  - Costallat LT
FAU - Samara, Adil M
AU  - Samara AM
FAU - Bertolo, Manoel B
AU  - Bertolo MB
LA  - eng
PT  - Journal Article
DEP - 20070824
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*27:05 antigen)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adult
MH  - Arthritis, Reactive/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - HLA-B27 Antigen
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Spondylarthropathies/*genetics
EDAT- 2007/08/25 09:00
MHDA- 2008/10/10 09:00
CRDT- 2007/08/25 09:00
PHST- 2007/04/10 00:00 [received]
PHST- 2007/07/29 00:00 [accepted]
PHST- 2007/08/25 09:00 [pubmed]
PHST- 2008/10/10 09:00 [medline]
PHST- 2007/08/25 09:00 [entrez]
AID - 10.1007/s00296-007-0441-3 [doi]
PST - ppublish
SO  - Rheumatol Int. 2008 Mar;28(5):483-6. doi: 10.1007/s00296-007-0441-3. Epub 2007 
      Aug 24.