PMID- 17719180
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20220310
IS  - 0306-4522 (Print)
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 148
IP  - 4
DP  - 2007 Sep 21
TI  - BDNF and learning: Evidence that instrumental training promotes learning within 
      the spinal cord by up-regulating BDNF expression.
PG  - 893-906
AB  - We have previously shown that the spinal cord is capable of learning a 
      sensorimotor task in the absence of supraspinal input. Given the action of 
      brain-derived neurotrophic factor (BDNF) on hippocampal learning, the current 
      studies examined the role of BDNF in spinal learning. BDNF is a strong synaptic 
      facilitator and, in association with other molecular signals (e.g. cAMP-response 
      element binding protein (CREB), calcium/calmodulin activated protein kinase II 
      (CaMKII) and synapsin I), important for learning. Spinally transected rats given 
      shock to one hind leg when the leg extended beyond a selected threshold exhibited 
      a progressive increase in flexion duration that minimized shock exposure, a 
      simple form of instrumental learning. Instrumental learning resulted in elevated 
      mRNA levels of BDNF, CaMKII, CREB, and synapsin I in the lumbar spinal cord 
      region. The increases in BDNF, CREB, and CaMKII were proportional to the learning 
      performance. Prior work has shown that instrumental training facilitates learning 
      when subjects are tested on the contralateral leg with a higher response 
      criterion. Pretreatment with the BDNF inhibitor TrkB-IgG blocked this 
      facilitatory effect, as did the CaMKII inhibitor AIP. Intrathecal administration 
      of BDNF facilitated learning when subjects were tested with a high response 
      criterion. The findings indicate that instrumental training enables learning and 
      elevates BDNF mRNA levels within the lumbar spinal cord. BDNF is both necessary, 
      and sufficient, to produce the enabling effect.
FAU - Gomez-Pinilla, F
AU  - Gomez-Pinilla F
AD  - Division of Neurosurgery, UCLA Brain Injury Research Center, USA. 
      fgomezpi@ucla.edu
FAU - Huie, J R
AU  - Huie JR
FAU - Ying, Z
AU  - Ying Z
FAU - Ferguson, A R
AU  - Ferguson AR
FAU - Crown, E D
AU  - Crown ED
FAU - Baumbauer, K M
AU  - Baumbauer KM
FAU - Edgerton, V R
AU  - Edgerton VR
FAU - Grau, J W
AU  - Grau JW
LA  - eng
GR  - R01 NS045804-03/NS/NINDS NIH HHS/United States
GR  - R01 NS045804/NS/NINDS NIH HHS/United States
GR  - NS45804/NS/NINDS NIH HHS/United States
GR  - NS41548/NS/NINDS NIH HHS/United States
GR  - R01 NS041548/NS/NINDS NIH HHS/United States
GR  - R01 NS045804-04/NS/NINDS NIH HHS/United States
GR  - P01 NS016333/NS/NINDS NIH HHS/United States
GR  - NS16333/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070823
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Synapsins)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/pharmacology/*physiology
MH  - CREB-Binding Protein/genetics/metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/metabolism
MH  - Conditioning, Operant/drug effects/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Inhibitors/pharmacology
MH  - Inhibition, Psychological
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/*metabolism
MH  - Spinal Cord Injuries/metabolism/pathology/rehabilitation
MH  - Synapsins/genetics/metabolism
MH  - *Teaching
MH  - Up-Regulation/drug effects/*physiology
PMC - PMC3225191
MID - NIHMS31786
EDAT- 2007/08/28 09:00
MHDA- 2008/02/15 09:00
PMCR- 2011/11/28
CRDT- 2007/08/28 09:00
PHST- 2007/01/23 00:00 [received]
PHST- 2007/04/24 00:00 [revised]
PHST- 2007/05/22 00:00 [accepted]
PHST- 2007/08/28 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2007/08/28 09:00 [entrez]
PHST- 2011/11/28 00:00 [pmc-release]
AID - S0306-4522(07)00639-2 [pii]
AID - 10.1016/j.neuroscience.2007.05.051 [doi]
PST - ppublish
SO  - Neuroscience. 2007 Sep 21;148(4):893-906. doi: 
      10.1016/j.neuroscience.2007.05.051. Epub 2007 Aug 23.