PMID- 17725924
OWN - NLM
STAT- MEDLINE
DCOM- 20080107
LR  - 20220408
IS  - 1710-3568 (Print)
IS  - 1710-3568 (Linking)
VI  - 18
IP  - 3
DP  - 2007 Sep
TI  - Cyclosporin A treatment is associated with increased serum immunoglobulin E 
      levels in a subgroup of atopic dermatitis patients.
PG  - 163-5
AB  - Cyclosporin A is increasingly used in the treatment of severe refractory atopic 
      dermatitis. Although cyclosporin A treatment is highly efficacious and relatively 
      safe, we report four adult atopic dermatitis (AD) patients who deteriorated 
      during long-term cyclosporin A treatment, with clinical signs and symptoms more 
      severe than at the onset of treatment. Interestingly, these patients showed large 
      increases of total serum immunoglobulin E (IgE) levels, paralleled by increasing 
      disease severity and serum levels of thymus and activation-regulated chemokine. 
      This implies that cyclosporin A may induce a shift to Th2, resulting in increased 
      IgE synthesis, in a subpopulation of AD patients. We therefore suggest that in 
      this subpopulation, treatment with anti-B cell or combined anti-B and T-cell 
      treatment may be favorable.
FAU - Hijnen, Dirk Jan
AU  - Hijnen DJ
AD  - University Medical Center Utrecht, Department of Dermatology & Allergology, The 
      Netherlands. D.J.Hijnen@umcutrecht.nl
FAU - Knol, Edward
AU  - Knol E
FAU - Bruijnzeel-Koomen, Carla
AU  - Bruijnzeel-Koomen C
FAU - de Bruin-Weller, Marjolein
AU  - de Bruin-Weller M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Dermatitis
JT  - Dermatitis : contact, atopic, occupational, drug
JID - 101207335
RN  - 0 (Immunosuppressive Agents)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Adult
MH  - Cyclosporine/administration & dosage/*adverse effects
MH  - Dermatitis, Atopic/blood/*drug therapy/immunology/pathology
MH  - Diagnosis, Differential
MH  - Eczema/chemically induced/*diagnosis/pathology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunosuppressive Agents/administration & dosage/*adverse effects
EDAT- 2007/08/30 09:00
MHDA- 2008/01/08 09:00
CRDT- 2007/08/30 09:00
PHST- 2007/08/30 09:00 [pubmed]
PHST- 2008/01/08 09:00 [medline]
PHST- 2007/08/30 09:00 [entrez]
AID - 10.2310/6620.2007.06025 [doi]
PST - ppublish
SO  - Dermatitis. 2007 Sep;18(3):163-5. doi: 10.2310/6620.2007.06025.