PMID- 17726474
OWN - NLM
STAT- MEDLINE
DCOM- 20080104
LR  - 20220408
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 10
IP  - 9
DP  - 2007 Sep
TI  - New insights into BDNF function in depression and anxiety.
PG  - 1089-93
AB  - The 'neurotrophin hypothesis of depression' is based largely on correlations 
      between stress or antidepressant treatment and down- or upregulation, 
      respectively, of brain-derived neurotrophic factor (BDNF). Genetic disruption of 
      the signaling pathways involving BDNF and its receptor, the tyrosine kinase TrkB, 
      does not seem to cause depressive behaviors, but does hamper the effect of 
      antidepressant drugs. Thus, BDNF may be a target of antidepressants, but not the 
      sole mediator of depression or anxiety. Advances in BDNF cell biology, including 
      its transcription through multiple promoters, trafficking and secretion, may 
      provide new insights into its role in mood disorders. Moreover, as the precursor 
      proBDNF and the mature protein mBDNF can elicit opposite effects on cellular 
      functions, the impact of proBDNF and its cleavage on mood should be considered. 
      Opposing influences of mBDNF and proBDNF on long-term potentiation and long-term 
      depression might contribute to the dichotomy of BDNF actions on behaviors 
      mediated by the brain stress and reward systems.
FAU - Martinowich, Keri
AU  - Martinowich K
AD  - Mood and Anxiety Program, National Institute of Mental Health, Building 35, Room 
      1C1004, 35 Convent Drive, MSC 3714, Bethesda, Maryland 20892-3714, USA.
FAU - Manji, Husseini
AU  - Manji H
FAU - Lu, Bai
AU  - Lu B
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - Anxiety/drug therapy/*genetics/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Depression/drug therapy/*genetics/*metabolism
MH  - Humans
MH  - Signal Transduction/physiology
RF  - 50
EDAT- 2007/08/30 09:00
MHDA- 2008/01/05 09:00
CRDT- 2007/08/30 09:00
PHST- 2007/08/30 09:00 [pubmed]
PHST- 2008/01/05 09:00 [medline]
PHST- 2007/08/30 09:00 [entrez]
AID - nn1971 [pii]
AID - 10.1038/nn1971 [doi]
PST - ppublish
SO  - Nat Neurosci. 2007 Sep;10(9):1089-93. doi: 10.1038/nn1971.