PMID- 17726642
OWN - NLM
STAT- MEDLINE
DCOM- 20080114
LR  - 20191210
IS  - 1058-0468 (Print)
IS  - 1573-7330 (Electronic)
IS  - 1058-0468 (Linking)
VI  - 24
IP  - 10
DP  - 2007 Oct
TI  - A normal birth following preimplantation genetic diagnosis by FISH determination 
      in the carriers of der(15)t(Y;15)(Yq12;15p11) translocations: two case reports.
PG  - 483-8
AB  - PURPOSE: To investigate the clinical application of fluorescence in situ 
      hybridization (FISH) for assessing chromosome disorders of embryos in 
      preimplantation diagnosis of carriers with der(15)t(Y;15)(q12;p11) 
      translocations. METHODS: Multicolor FISH was performed using directly-labelled 
      DNA probes, chromosome X with one (DXZ1, Xp11.1-q11.1), but Y with two (DYZ3, 
      Yp11.1-q11.1 and DYZ1, Yq12). Normal embryos were transferred on day 6 at 
      blastocyst stage. RESULTS: Couple A: Three of 6 biopsied embryos were normal. Two 
      normal blastocysts were transferred, but no pregnancy was achieved. Couple B: 
      Three of 6 biopsied embryos were normal. Two normal blastocysts were transferred. 
      A normal male infant weighing 3,230 g was born by cesarean section on the 39th 
      week of gestation. All of the remaining nonreplaced embryos showed mosaic or 
      der(15). CONCLUSION: Embryos from carries of der(15)t(Y;15)(q12;p11) 
      translocation showed a high frequency of chromosome abnormalities. PGD is a 
      valuable screen tool for those couples to treat their infertility and break the 
      transmission of der(15) chromosome for their offspring.
FAU - Chen, Yongjian
AU  - Chen Y
AD  - The Center of Reproductive Medicine, Peking University Third Hospital, Beijing 
      100083, China.
FAU - Chen, Guian
AU  - Chen G
FAU - Lian, Ying
AU  - Lian Y
FAU - Gao, Xuefeng
AU  - Gao X
FAU - Huang, Jin
AU  - Huang J
FAU - Qiao, Jie
AU  - Qiao J
LA  - eng
PT  - Case Reports
PT  - Evaluation Study
PT  - Journal Article
DEP - 20070829
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
SB  - IM
MH  - Chromosomes, Human, Pair 15/*genetics
MH  - Chromosomes, Human, Y/*genetics
MH  - Embryo, Mammalian/pathology
MH  - Female
MH  - Genetic Carrier Screening/*methods
MH  - Heterozygote
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Infant, Newborn
MH  - Karyotyping
MH  - Live Birth
MH  - Male
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*methods
MH  - Sperm Injections, Intracytoplasmic
MH  - *Translocation, Genetic
PMC - PMC3455077
EDAT- 2007/08/30 09:00
MHDA- 2008/01/15 09:00
PMCR- 2008/10/01
CRDT- 2007/08/30 09:00
PHST- 2007/05/29 00:00 [received]
PHST- 2007/07/26 00:00 [accepted]
PHST- 2007/08/30 09:00 [pubmed]
PHST- 2008/01/15 09:00 [medline]
PHST- 2007/08/30 09:00 [entrez]
PHST- 2008/10/01 00:00 [pmc-release]
AID - 9163 [pii]
AID - 10.1007/s10815-007-9163-4 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 2007 Oct;24(10):483-8. doi: 10.1007/s10815-007-9163-4. 
      Epub 2007 Aug 29.