PMID- 17726746
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20181113
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 8
IP  - 9
DP  - 2007 Sep
TI  - Cell therapy in congestive heart failure.
PG  - 647-60
AB  - Congestive heart failure (CHF) has emerged as a major worldwide epidemic and its 
      main causes seem to be the aging of the population and the survival of patients 
      with post-myocardial infarction. Cardiomyocyte dropout (necrosis and apoptosis) 
      plays a critical role in the progress of CHF; thus treatment of CHF by exogenous 
      cell implantation will be a promising medical approach. In the acute phase of 
      cardiac damage cardiac stem cells (CSCs) within the heart divide symmetrically 
      and/or asymmetrically in response to the change of heart homeostasis, and at the 
      same time homing of bone marrow stem cells (BMCs) to injured area is thought to 
      occur, which not only reconstitutes CSC population to normal levels but also 
      repairs the heart by differentiation into cardiac tissue. So far, basic studies 
      by using potential sources such as BMCs and CSCs to treat animal CHF have shown 
      improved ventricular remodelling and heart function. Recently, however, a few of 
      randomized, double-blind, placebo-controlled clinical trials demonstrated mixed 
      results in heart failure with BMC therapy during acute myocardial infarction.
FAU - Tao, Ze-wei
AU  - Tao ZW
AD  - Department of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical 
      University, Chongqing 400037, China. taozw@hotmail.com
FAU - Li, Long-gui
AU  - Li LG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic/trends
MH  - Heart Failure/*pathology/*surgery
MH  - Humans
MH  - Mesenchymal Stem Cell Transplantation/*methods/trends
MH  - Myocytes, Cardiac/*transplantation
MH  - Practice Guidelines as Topic
MH  - Practice Patterns, Physicians'/trends
PMC - PMC1963431
EDAT- 2007/08/30 09:00
MHDA- 2007/11/14 09:00
PMCR- 2007/09/01
CRDT- 2007/08/30 09:00
PHST- 2007/08/30 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/08/30 09:00 [entrez]
PHST- 2007/09/01 00:00 [pmc-release]
AID - 10.1631/jzus.2007.B0647 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2007 Sep;8(9):647-60. doi: 10.1631/jzus.2007.B0647.