PMID- 17727684
OWN - NLM
STAT- MEDLINE
DCOM- 20071214
LR  - 20220408
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Linking)
VI  - 98
IP  - 11
DP  - 2007 Nov
TI  - Functional implications of tetraspanin proteins in cancer biology.
PG  - 1666-77
AB  - Human tetraspanin proteins are a group of 33 highly hydrophobic membrane proteins 
      that can form complexes in cholesterol-rich microdomains, distinct from lipid 
      rafts, on the cell surface in a dynamic and reversible way. These complexes are 
      composed of a core of several tetraspanin proteins that organize other membrane 
      proteins such as integrins, human leukocyte antigen (HLA) antigens and some 
      growth factor receptors. Although most tetraspanin proteins have been studied 
      individually, tetraspanin proteins and their complexes can have effects on 
      cellular adhesion and motility, interactions with stroma or affect signaling by 
      growth factors, and for most of them no ligand has been identified. Functionally 
      these proteins have been mostly studied in cells of lymphoid lineage, but they 
      are present in all cell types. Data is also available for some tumors, where some 
      tetraspanins have been identified as metastasis suppressors, but their 
      significance is still not clear. Some of their implications in tumor biology and 
      the areas that deserve further study are outlined.
FAU - Lazo, Pedro A
AU  - Lazo PA
AD  - Programa de Oncologia Translacional, Instituto de Biologia Molecular y Celular 
      del Cancer, Centro de Investigacion del Cancer, CSIC-Universidad de Salamanca, 
      Salamanca, E-37007, Spain. plazozbi@usal.es
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070824
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (Antigens, CD)
RN  - 0 (Gangliosides)
RN  - 0 (HLA Antigens)
RN  - 0 (Integrins)
RN  - 0 (Membrane Lipids)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proteome)
RN  - 0 (Receptors, Growth Factor)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Antigens, CD/physiology
MH  - Cholesterol/physiology
MH  - Gangliosides/physiology
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Integrins/*physiology
MH  - Membrane Lipids/physiology
MH  - Membrane Proteins/genetics/*physiology
MH  - Neoplasm Proteins/physiology
MH  - Neoplasms/immunology/*physiopathology
MH  - Proteome
MH  - Receptors, Growth Factor/physiology
RF  - 159
EDAT- 2007/08/31 09:00
MHDA- 2007/12/15 09:00
CRDT- 2007/08/31 09:00
PHST- 2007/08/31 09:00 [pubmed]
PHST- 2007/12/15 09:00 [medline]
PHST- 2007/08/31 09:00 [entrez]
AID - CAS584 [pii]
AID - 10.1111/j.1349-7006.2007.00584.x [doi]
PST - ppublish
SO  - Cancer Sci. 2007 Nov;98(11):1666-77. doi: 10.1111/j.1349-7006.2007.00584.x. Epub 
      2007 Aug 24.