PMID- 17728116
OWN - NLM
STAT- MEDLINE
DCOM- 20080430
LR  - 20220311
IS  - 0927-7765 (Print)
IS  - 0927-7765 (Linking)
VI  - 61
IP  - 1
DP  - 2008 Jan 15
TI  - The effect of pharmaceuticals on the nanoscale structure of PEO-PPO-PEO micelles.
PG  - 53-60
AB  - We present results on the effects of various hydrophobic drugs and additives on 
      the micellar structure of Pluronic F127 solutions. Small-angle neutron scattering 
      experiments on 5wt% F127 solutions were used to measure micelle core size (R(1)), 
      micelle corona size (R(2)), intermicellar interaction distance (R(int)), 
      polydispersity (sigma), and aggregation number (N(agg)); dynamic light scattering 
      was used to measure critical micelle concentration (CMC); and ultraviolet 
      spectroscopy was used to measure drug solubility and apparent micelle-water 
      partition coefficient (K(mw)). The core and corona size were found to generally 
      increase in the presence of the drugs, as did R(int). Both sigma and N(agg) were 
      found to decrease in the presence of most of the drugs, and the CMC was found to 
      vary considerably with no clear correlation. A design of experiments (DOE) 
      approach was used to analyze the results and build empirical correlations. All of 
      the parameters from the SANS experiments were found to depend strongly on drug 
      solubility, with a weak dependence on K(mw) in most cases. The aggregation 
      number, however, was found to depend strongly on both K(mw) and solubility. The 
      correlations can be used to roughly predict the structural parameters of F127 
      micelles for other hydrophobic drugs.
FAU - Sharma, Praveen K
AU  - Sharma PK
AD  - Department of Chemical Engineering, 159 Goessmann Laboratory, University of 
      Massachusetts, Amherst, MA 01003-9303, USA.
FAU - Reilly, Meghan J
AU  - Reilly MJ
FAU - Jones, Deanna N
AU  - Jones DN
FAU - Robinson, Paul M
AU  - Robinson PM
FAU - Bhatia, Surita R
AU  - Bhatia SR
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070719
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Micelles)
RN  - 0 (Pharmaceutical Preparations)
RN  - 106392-12-5 (Poloxamer)
SB  - IM
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Light
MH  - *Micelles
MH  - Neutron Diffraction
MH  - *Pharmaceutical Preparations/administration & dosage
MH  - Poloxamer/*chemistry
MH  - Research Design
MH  - Scattering, Radiation
MH  - Scattering, Small Angle
MH  - Solubility
MH  - Spectrophotometry, Ultraviolet
EDAT- 2007/08/31 09:00
MHDA- 2008/05/01 09:00
CRDT- 2007/08/31 09:00
PHST- 2007/06/06 00:00 [received]
PHST- 2007/07/09 00:00 [revised]
PHST- 2007/07/12 00:00 [accepted]
PHST- 2007/08/31 09:00 [pubmed]
PHST- 2008/05/01 09:00 [medline]
PHST- 2007/08/31 09:00 [entrez]
AID - S0927-7765(07)00282-2 [pii]
AID - 10.1016/j.colsurfb.2007.07.002 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2008 Jan 15;61(1):53-60. doi: 
      10.1016/j.colsurfb.2007.07.002. Epub 2007 Jul 19.