PMID- 17728444
OWN - NLM
STAT- MEDLINE
DCOM- 20070925
LR  - 20220317
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 27
IP  - 35
DP  - 2007 Aug 29
TI  - Chronic interleukin-1beta expression in mouse brain leads to leukocyte 
      infiltration and neutrophil-independent blood brain barrier permeability without 
      overt neurodegeneration.
PG  - 9301-9
AB  - The proinflammatory cytokine interleukin-1beta (IL-1beta) plays a significant 
      role in leukocyte recruitment to the CNS. Although acute effects of IL-1beta 
      signaling in the mouse brain have been well described, studies elucidating the 
      downstream effects of sustained upregulation have been lacking. Using the 
      recently described IL-1beta(XAT) transgenic mouse model, we triggered sustained 
      unilateral hippocampal overexpression of IL-1beta. Transgene induction led to 
      blood-brain barrier leakage, induction of MCP-1 (monocyte chemoattractant protein 
      1) (CCL2), ICAM-1 (intercellular adhesion molecule 1), and dramatic infiltration 
      of CD45-positive leukocytes comprised of neutrophils, T-cells, macrophages, and 
      dendritic cells. Despite prolonged cellular infiltration of the hippocampus, 
      there was no evidence of neuronal degeneration. Surprisingly, neutrophils were 
      observed in the hippocampal parenchyma as late as 1 year after transgene 
      induction. Their presence was coincident with upregulation of the potent 
      neutrophil chemotactic chemokines KC (keratinocyte-derived chemokine) (CXCL1) and 
      MIP-2 (macrophage inflammatory protein 2) (CXCL2). Knock-out of their sole 
      receptor CXCR2 abrogated neutrophil infiltration but failed to reduce leakage of 
      the blood-brain barrier.
FAU - Shaftel, Solomon S
AU  - Shaftel SS
AD  - Department of Neurobiology and Anatomy, University of Rochester School of 
      Medicine and Dentistry, Rochester, New York 14642, USA.
FAU - Carlson, Thaddeus J
AU  - Carlson TJ
FAU - Olschowka, John A
AU  - Olschowka JA
FAU - Kyrkanides, Stephanos
AU  - Kyrkanides S
FAU - Matousek, Sarah B
AU  - Matousek SB
FAU - O'Banion, M Kerry
AU  - O'Banion MK
LA  - eng
GR  - R01 NS033553/NS/NINDS NIH HHS/United States
GR  - R21 NS048522/NS/NINDS NIH HHS/United States
GR  - R29 NS033553/NS/NINDS NIH HHS/United States
GR  - T32 GM007356/GM/NIGMS NIH HHS/United States
GR  - NS048522/NS/NINDS NIH HHS/United States
GR  - NS33553/NS/NINDS NIH HHS/United States
GR  - GM07356/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL2)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Monokines)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*physiology
MH  - Chemokine CCL2/metabolism
MH  - Chemokine CXCL2
MH  - Hippocampus/*metabolism
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Interleukin-1beta/genetics/*metabolism
MH  - Leukocyte Common Antigens/metabolism
MH  - Leukocytes/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Monokines/deficiency/metabolism
MH  - Neutrophils/*metabolism
MH  - Up-Regulation/*physiology
PMC - PMC6673122
EDAT- 2007/08/31 09:00
MHDA- 2007/09/26 09:00
PMCR- 2008/02/29
CRDT- 2007/08/31 09:00
PHST- 2007/08/31 09:00 [pubmed]
PHST- 2007/09/26 09:00 [medline]
PHST- 2007/08/31 09:00 [entrez]
PHST- 2008/02/29 00:00 [pmc-release]
AID - 27/35/9301 [pii]
AID - 3257729 [pii]
AID - 10.1523/JNEUROSCI.1418-07.2007 [doi]
PST - ppublish
SO  - J Neurosci. 2007 Aug 29;27(35):9301-9. doi: 10.1523/JNEUROSCI.1418-07.2007.